2/2 Ponce School of Medicine-Moffitt Cancer Center Partnership

项目总结/摘要 庞塞健康科学大学（PHSU）和莫菲特癌症中心（MCC）已经建立了一个 建立在无缝沟通基础上的强大的工作关系，相互支持和利益。与 伙伴关系资源和两个机构的重大承诺，我们建立了联合计划 加强基础和临床研究，丰富癌症外展，扩大癌症教育，并创造一个 独特的西班牙裔/拉丁裔（H/L）生物库，导致强大的网络和基础设施的发展 这是一个持续的长期合作，以改善H/L人群的癌症结果所必需的。U54 伙伴关系的直接影响包括在H/L中识别乳腺癌和肺癌的新突变 患者，招聘对可持续发展和增长至关重要的新教师，以及84个社区外展 在佛罗里达（FL）和波多黎各（PR）为H/L举办教育活动。波多黎各的发展 生物库（PRBB）和临床研究人员的培训，在庞塞启动了25项临床干预试验， 展示通过伙伴关系实现的广泛影响。此外，伙伴关系还发挥着关键作用， 在ACGME重新认证的血液学/肿瘤学奖学金在公关，在建立两个干 细胞移植计划在PR由研究员在MCC骨髓移植单位培训，并在 在Ponce建立ACGME认证的外科住院医师，并在MCC进行外科肿瘤学轮换。 U 54伙伴关系赠款的前4年的短期指标包括48名学生参与者，35 出版了经同行评审的手稿，在总共提交的64份手稿中，有29份获得了赠款。 我们对U 54 PACHE更新的愿景是进一步发展和参与教师和学生在癌症 精准医学研究，直接影响佛罗里达州和PR的H/L人群。该伙伴关系具有 在服务不足的人群中全面实施精准医疗的必要组成部分-生物库， 定量科学核心（QSC）分析数据，文化敏感的宣传材料，最新的专业知识 技术和强大的研究组合。U 54伙伴关系更新的四个具体目标是： 以下.目标1：增加PHSU专注于基础/转化研究的研究人员数量， 增加MCC癌症健康差异研究人员的数量。这是由以下因素促成的： 卵巢癌和乳腺癌的联合项目。目标2：进一步发展外联方案和研究工作 在PHSU和MCC的H/L社区。一个流行病学项目将审查接收的影响， MC 1 R基因型对个人防晒行为的影响。目标3：增加对基本的、翻译性的 和临床研究的H/L人群中建立的QSC和进一步发展PRBB。的 MCC全面癌症护理方案将在庞塞医院制定，并由PRBB利用，以促进 组织收集。目标4：在PHSU提供全面和结构化的学生研究教育 和MCC，以促进癌症研究人员和临床医生在H/L人群中的扩展和成功。

PROJECT SUMMARY/ABSTRACT The Ponce Health Sciences University (PHSU) and the Moffitt Cancer Center (MCC) have forged a strong working relationship founded on seamless communication with mutual support and benefits. With Partnership resources and significant commitment from both institutions, we have established joint programs enhancing basic and clinical research, enriching cancer outreach, expanding cancer education, and creating a unique Hispanic/Latino (H/L) Biobank, leading to the development of a robust network and infrastructure necessary for a sustained long-term collaboration to improve cancer outcomes in the H/L population. The U54 Partnership’s immediate impact includes the identification of new mutations in breast and lung cancer in H/L patients, recruitment of new faculty essential for sustainability and growth, and 84 community outreach educational activities for H/Ls in Florida (FL) and Puerto Rico (PR). The development of the Puerto Rico Biobank (PRBB) and the training of clinical researchers, with 25 clinical intervention trials activated in Ponce, demonstrate the broad impact realized through the Partnership. Furthermore the Partnership had a critical role in the ACGME re-accreditation of the Hematology/Oncology Fellowship in PR, in the establishment of two stem cell transplant programs in PR by fellows trained in the MCC Bone Marrow Transplant unit, and in the establishment of an ACGME-accredited surgical residency in Ponce with surgical oncology rotations at MCC. The short-term metrics of the first 4 years of the U54 Partnership grant include 48 student participants, 35 peer-reviewed manuscripts published, and 29 grants funded out of a total of 64 submitted. Our vision for the U54 PACHE renewal is to further grow and engage faculty and students in cancer precision medicine research that directly impacts the H/L populations in FL and PR. The Partnership has the requisite components to fully execute precision medicine in an underserved population—a biobank, quantitative science core (QSC) to analyze data, culturally sensitive outreach materials, expertise in the latest technologies, and a robust research portfolio. The four specific aims for the U54 Partnership renewal are the following. Aim 1: To increase the number of researchers at PHSU focused on basic/translational research in cancer and to augment the number of researchers in cancer health disparities at MCC. This is facilitated with joint projects in ovarian and breast cancer. Aim 2: To further develop outreach programs and research efforts in the H/L communities at both PHSU and MCC. An epidemiological project will examine the impact of receipt of MC1R genotypes on personal sun protection behaviors. Aim 3: To increase support for basic, translational and clinical research in the H/L population by establishing the QSC and further developing the PRBB. The MCC Total Cancer Care protocol will be developed in Ponce hospitals and leveraged by the PRBB to facilitate tissue collection. Aim 4: To provide comprehensive and structured student research education at both PHSU and MCC to facilitate the expansion and success of cancer researchers and clinicians in the H/L population.