UCLA LIFT-UP (Leveraging Institutional support For Talented, Underrepresented Physicians and/or Scientists)

项目摘要/摘要 加州大学洛杉矶分校的提升(利用机构对有才华、代表性不足的医生和/或 科学家)，建议开发一项研究和指导计划，这将有助于 追求与NIDDK使命相一致的研究职业的科学工作者。我们的领导团队有一个 在支持博士后研究员和终身教职教师方面取得了良好的成绩 代表不足的群体(URG)获得外部研究资金并取得研究独立性的进展。 拟议的多个PIs共同领导一个类似的、非常成功的P30少数民族老龄化研究中心 (RCMAR)来自NIA，在过去的一年中招募、聘用和支持了61名早期职业URG研究人员 21年来，这两个多项私人投资机构在过去20年中都有NIDDK资金的强劲记录。我们会的 能够利用我们在糖尿病护理领域的研究、临床、政策和计划评估专业知识 和预防在整个南加州识别和/或培养有才华的URG研究人员。 UCLA Lift Up建立在UCLA CTSI、UCLA医学部和 加州大学洛杉矶分校菲尔丁公共卫生学院。我们提出了三个提升计划核心--管理核心 (AC)、研究指导核心(RMC)和研究支持核心(RSC)。RMC和RSC将各自 由一名基础科学家和一名临床成果/健康服务研究人员共同领导，以加强协调 为翻译研究领域的研究人员提供研究指导和研究支持。至 要实现这些目标，加州大学洛杉矶分校的总体目标是： 1.提供所需的全面指导，以促进14-17学年的学业成功 早期URG研究人员通过指导和试点研究奖在肥胖和 跨翻译研究领域的糖尿病； 2.让URG研究人员参与以实验室为基础的尖端科学，推动机械 了解与肥胖、胰岛素抵抗、糖尿病、 及相关条件； 3.发展改善肥胖和/或患者健康所需的研究基础设施 通过社区和卫生系统的发展、实施和评估而患上糖尿病 旨在缓解健康差距的合作干预措施和政策。 提升的目标将是指导和发展高技能的早期职业URG科学家，他们的热情 事业致力于预防和治疗肥胖症和糖尿病，努力实现健康公平 在与NIDDK使命一致的疾病领域。我们将通过积极确定 在南加州招募最有才华的URG候选人，并将他们植入最强大的公司， 最全面的教师发展计划。

PROJECT SUMMARY/ABSTRACT UCLA LIFT-UP (Leveraging Institutional support For Talented, Underrepresented Physicians and/or Scientists), proposes to develop a research and mentoring program that will contribute to diversity in the scientific workforce pursuing research careers aligned with the NIDDK mission. Our leadership team has a strong record of accomplishment in supporting post-doctoral fellows and pre-tenured faculty from underrepresented groups (URG) obtain external research funding and progress to research independence. The proposed multi-PIs co-lead a similar, highly successful P30 Research Centers for Minority Aging Research (RCMAR) from NIA that has recruited, engaged, and supported 61 early-career URG researchers over the last 21 years, and both multi-PIs have a strong record of NIDDK funding over the last two decades. We will be able to leverage our research, clinical, policy, and program evaluation expertise in the area of diabetes care and prevention in identifying and/or developing talented URG researchers throughout Southern California. UCLA LIFT-UP builds on the scientific strengths in the UCLA CTSI, UCLA Department of Medicine, and the UCLA Fielding School of Public Health. We propose three LIFT-UP Program Cores - an Administrative Core (AC), Research Mentorship Core (RMC), and Research Support Core (RSC). The RMC and the RSC will each be co-led by a basic scientist and a clinical outcomes/health services researcher, to enhance coordination of research mentorship and research support for investigators across the translational research spectrum. To accomplish these goals, the UCLA LIFT-UP overarching Specific Aims are to: 1. Provide the comprehensive guidance required to promote successful academic advancement of 14-17 early URG researchers through mentorship and pilot research awards in the areas of obesity and diabetes across the translational research spectrum; 2. Engage URG researchers in cutting-edge laboratory-based science that advances the mechanistic understanding of molecular and physiologic processes related to obesity, insulin resistance, diabetes, and related conditions; 3. Develop the research infrastructure needed to improve the health of patients with obesity and/or diabetes through the development, implementation, and evaluation of community and health system partnered interventions and policies designed to mitigate health disparities. The goal of LIFT-UP will be to mentor and develop highly skilled early career URG scientists whose passion and careers are devoted to preventing and treating obesity and diabetes, and working to achieve health equity in disease areas aligned with the mission of the NIDDK. We will accomplish this by aggressively identifying and recruiting the most talented URG candidates in Southern California and embedding them in the strongest, most comprehensive faculty development program possible.