Activin A and follistatin are potential key regulators of organ transplant dysfunction and graft survival.

这项拨款研究了器官移植中的新的关键调控因素。它检查在移植手术期间和血液回流到器官时释放的分子，这可能会导致炎症和疤痕。肝素是一种用于器官准备的抗凝血剂，它可以增加释放。将对释放的调节剂的替代抗凝剂和阻滞剂进行测试，以防止对移植的损害，潜在地改善移植物的短期和长期存活和功能。

The grant examines novel key regulators in organ transplantation. It examines molecules that are released during transplant surgery and on the return of blood flow to the organ which can cause inflammation and scarring. The release is increased by heparin, an anticoagulant used in organ preparation. Alternative anticoagulants and blockers of the regulators released will be tested to prevent the damage to the transplant, potentially improving both the short and long term graft survival and function.