Islet & Physiology Core

摘要（胰岛和生理核心） 胰岛和生理学核心支持印第安纳州糖尿病研究中心（IDRC）的总体使命， 促进合作，支持培训，促进糖尿病和相关代谢的前沿研究 通过在啮齿动物胰岛隔离中提供全面和最先进的服务来治疗疾病;斑马鱼，啮齿动物， 猪和人胰岛表征;人、啮齿动物和猪胰岛移植;和啮齿动物代谢 表型分析胰岛和生理学核心支持来自印第安纳州大学的IDRC调查人员的工作 医学院（IUSM）及其附属机构，与成员密切合作，提供“包装- “围绕”服务，包括协助实验设计，有效执行实验， 协助数据分析和解释。核心服务于经验丰富的以及新手用户 并作为一个重要的渠道，为那些没有 传统上研究胰岛或进行代谢研究。除了咨询性和实验性 服务，核心为希望将专业技术重新纳入 自己的实验室。中心主任是C博士。埃文斯-莫利纳，副主任是博士。泰西，还有 助理主任是R博士安德森。领导层由一组技术人员协助，并由 咨询委员会。该核心与IDRC翻译核心、显微镜核心、系统和 Informatics Core和Swine Core，以满足我们用户群的实验需求，同时也坚持 最高标准的严谨性、再现性、精炼和还原。该核心将实现以下目标： (1)为IDRC研究人员提供高质量的啮齿动物胰岛，并促进采购 人和猪的胰岛和胰腺组织用于分析。 (2)提供最先进的人类、啮齿动物、斑马鱼和猪胰岛和胰腺表征 服务 (3)提供最先进的啮齿动物代谢分析，包括葡萄糖和胰岛素评估 耐受性、身体组成、能量消耗、活动水平和食物摄入。 (4)提供量身定制的咨询服务和培训，以满足经验丰富的 用户和用户谁是新的糖尿病和代谢研究。 （五）、确保核心服务不断发展，以满足IDRC调查员的需求，并与新的 领域的发展

ABSTRACT (ISLET & PHYSIOLOGY CORE) The Islet & Physiology Core supports the overall mission of the Indiana Diabetes Research Center (IDRC) to foster collaboration, support training, and promote cutting edge research in diabetes and related metabolic disorders by providing comprehensive and state-of-the art services in rodent islet isolation; zebrafish, rodent, swine, and human islet characterization; human, rodent, and swine islet transplantation; and rodent metabolic phenotyping. The Islet and Physiology Core supports the work of IDRC investigators from Indiana University School of Medicine (IUSM) and its affiliated institutions, working closely with members to provide “wrap- around” services that include assistance with experimental design, efficient execution of experiments, and assistance with data analysis and interpretation. The Core serves both experienced as well as novice users and functions as an important conduit for facilitating entry into the field for investigators who have not traditionally worked with islets or performed metabolic research. In addition to consultative and experimental services, the Core provides training for investigators who wish to incorporate specialized techniques back into their own lab. The Director of the Core is Dr. C. Evans-Molina, the Associate Director is Dr. S. Tersey, and the Assistant Director is Dr. R. Anderson. The leadership is assisted by a crew of technical staff and advised by an Advisory Board. The Core closely interfaces with the IDRC Translation Core, Microscopy Core, Systems & Informatics Core, and Swine Core to meet the experimental needs of our user base, while also adhering to the highest standards of rigor, reproducibility, refinement, and reduction. The Core will achieve the following aims: (1) To provide IDRC investigators with high quality rodent islets and facilitate the procurement of human and swine islets and pancreatic tissues for analysis. (2) To provide state-of-the-art human, rodent, zebrafish and swine islet and pancreas characterization services. (3) To provide state-of-the art rodent metabolic analysis, including assessment of glucose and insulin tolerance, body composition, energy expenditure, activity levels, and food intake. (4) To provide consultation services and training that is tailored to fit the needs of both experienced users and users who are new diabetes and metabolic research. (5). To ensure that Core services evolve to meet IDRC investigator needs and keep pace with new developments in the field