The San Antonio Heart and Mind Study

摘要 阿尔茨海默病（AD）和AD相关痴呆（AD/ADRD）不成比例地影响少数群体， 人口。与非西班牙裔白人相比，美国的西班牙裔成年人估计 AD风险增加50%，预计到2060年AD/ADRD病例的相对增加最大。 墨西哥裔美国人不仅代表了美国最大的拉美裔群体，而且他们还 经历心脏代谢疾病的高负担，这有可能增加AD/ADRD的差异 在接下来的几十年里。然而，西班牙裔在流行病学环境中的代表性不足， 需要对这一种族群体进行研究，以确定导致AD/ADRD差异的因素。本课题 建议重新建立一个始于1979年的流行病学队列，研究糖尿病的种族差异， 心血管疾病圣安东尼奥心脏研究招募了5，158名墨西哥裔美国人和非西班牙裔白色 来自德克萨斯州圣安东尼奥的社会文化多样性社区的成年人。通过这笔赠款，幸存者将 我被邀请参加一项新的研究，该研究的重点是认知老化和AD/ADRD：圣安东尼奥心脏和精神研究 （SAHMS）。我们将对认知功能、脑MRI、淀粉样蛋白和tau PET进行全面评估， 测量血液和CSF生物标志物、心脏代谢疾病、心理社会属性，以及 社会文化因素。参与者还将被邀请参加我们的大脑捐赠计划， 特征化通过利用四十年前获得的和新收集的丰富的纵向数据集， 通过这项资助，我们有一个理想的环境，以更好地了解中年和晚年因素的作用 导致墨西哥裔美国老年人AD/ADRD差异。我们才华横溢的多学科团队提供 为这个项目的成功提供补充专业知识。我们的研究结果有可能为 制定卫生政策，在未来几十年内预防和延缓AD/ADRD，特别是在服务不足的人群中 墨西哥裔美国人。

ABSTRACT Alzheimer’s disease (AD) and AD-related dementias (AD/ADRD) disproportionately affect minoritized populations. Compared to non-Hispanic Whites, older Hispanic adults in the United States are estimated to have a 50% increased risk of AD and are projected to bear the largest relative increase in AD/ADRD cases by 2060. Mexican Americans not only represent the largest segment of Hispanics in the United States, but they also experience a high burden of cardiometabolic diseases, which has the potential to increase AD/ADRD disparities over the next decades. However, Hispanics are underrepresented in epidemiological settings and more research is needed on this ethnic group to identify the factors contributing to AD/ADRD disparities. In this project, we propose to re-establish an epidemiological cohort initiated in 1979 to study ethnic differences in diabetes and cardiovascular disease. The San Antonio Heart Study enrolled 5,158 Mexican American and non-Hispanic White adults from socioculturally diverse neighborhoods in San Antonio, Texas. Through this grant, survivors will be invited to a new study focused on cognitive aging and AD/ADRD: The San Antonio Heart and Mind Study (SAHMS). We will perform comprehensive assessments for cognitive function, brain MRI, amyloid and tau PET, the measurement of blood- and CSF-based biomarkers, cardiometabolic disease, psychosocial attributes, and sociocultural factors. Participants will also be invited to our brain donation program for further neuropathological characterization. By leveraging the rich set of longitudinal data obtained four decades ago and newly collected information through this grant, we have an ideal setting to better understand the role of midlife and late-life factors contributing to AD/ADRD disparities in Mexican American older adults. Our talented multidisciplinary team offers complementary expertise for the success of this project. Results from our study have the potential to inform health policies aiming to prevent and delay AD/ADRD over the next decades, especially in the underserved population of Mexican Americans.