Digital clinical hypnosis for chronic pain management

项目摘要 慢性疼痛是一个普遍存在的致残问题，在美国有1.16亿成年人受到影响。 然而，慢性疼痛管理的治疗选择很少，可用的是 对于大多数患有这种疾病的人来说，这是不够的。许多药物也有显著的副作用或 与重大不良事件相关。越来越多的研究支持短期和长期 催眠疗法对慢性疼痛的益处。催眠疗法也被证明有很少的负面作用。 副作用，同时在减轻疼痛强度之外还有其他好处，包括 减少焦虑，提高睡眠质量。然而，催眠治疗的途径是有限的。 因为很少有医疗保健提供者接受过使用它的培训。HypnoScience，Inc.的成立是为了增加 通过开发并在网上和移动设备上提供有效的催眠治疗， 即数字催眠。为了最大限度地发挥功效，HypnoScience的产品采用了来自油井的发现- 已建立和正在进行的研究催眠镇痛机制的计划，包括Pilot 测试催眠数字治疗原型的研究。当前拟议阶段的第一个目标 I项目是通过以下方式进一步开发催眠数字治疗原型：(1)更新和增加 提供催眠媒体曲目的数量，(2)设计内容交付规则集，(3)开发UI/UX 标准，以优化易用性和有效性，以及(4)开发一致的内容管理系统 有了这个规则集，就可以通过现有的 远程医疗公司的平台。该项目的第二个目标是评估技术交付的可行性 在50名慢性疼痛患者的样本中，AIM 1开发了这一系统。这些人将成为 随机获得更多访问权限(即，整整8周)或更少访问权限(即，4周未访问，然后是4周 试验期间和试验结束后，将收集获得治疗药物的时间和可行性变量。这个 这项试验的结果将使我们能够确定建议的催眠治疗方法是否更多地 数百万可能从中受益的个人可以使用它是可行的。调查结果还将提供数据 这将为设计在第二阶段项目中测试该技术的最终试验提供依据。

Project Summary Chronic pain is a prevalent, disabling problem affecting as many as 116 million adults in the United States. However, there are very few treatment options for chronic pain management, and those that are available are inadequate for the majority of those with this condition. Many also have significant negative side effects or are associated with significant adverse events. A growing body of research supports the short- and long-term benefits of hypnosis treatment for chronic pain. Hypnosis treatment has also been shown to have few negative side effects, while also having additional benefits over and above reductions in pain intensity, including reductions in anxiety and improvements in sleep quality. However, access to hypnosis treatment is limited because few health care providers are trained in its use. HypnoScientific, Inc. was established to increase access to effective hypnosis treatment by developing and making it available online and via mobile devices, i.e., digital hypnosis. To maximize efficacy, HypnoScientific’s products are informed by the findings from a well- established and ongoing research program studying the mechanisms of hypnotic analgesia, including pilot research that has tested a hypnosis digital therapeutic prototype. The first aim of the currently proposed Phase I project is to develop the hypnosis digital therapeutic prototype further by: (1) updating and increasing the number of hypnosis media tracks offered, (2) designing a ruleset for content delivery, (3) developing UI/UX standards to optimize ease of use and efficacy, and (4) developing a content management system consistent with this ruleset, that would allow content to be provided to individuals with chronic pain via an existing telehealth company’s platform. The project’s second aim is to evaluate the feasibility of the technology delivery system developed in Aim 1 in a sample of 50 individuals with chronic pain. These individuals will be randomized to having more access (i.e., 8 full weeks) or less access (i.e., 4 weeks of no access followed by 4 weeks of access) to the therapeutic, and feasibility variables will be collected during and after the trial. The findings from this trial will allow us to determine if the proposed approach for making hypnosis treatment more accessible to the millions of individuals who could benefit from it is viable. The findings will also provide data that will inform the design of a definitive trial testing the technology in a Phase II project.