P30 Center Core Grant for Vision Research

摘要 整体 此P30 Vision核心更新应用程序的目标是管理和维护现有和新的核心 设施，将提供专业知识，技术支持，设备访问和人员培训，为24 俄克拉荷马州大学健康科学中心的独立视觉研究实验室。我们有 两个高度利用和成功的核心：活体动物成像和功能分析核心（AAC）（具有 已与先前的基因分型核心合并），以及细胞成像和形态测定分析核心 （CIC）.在这次竞争性更新中，我们增加了一个新的眼部免疫生物学核心（OIC）， 设备，培训和专业知识，以满足我们对免疫学基础的快速增长的兴趣。 眼部疾病AAC（两个独立的模块）位于两个主要的动物园内， 这房子的大部分视觉研究动物在校园里，而CIC和OIC位于 眼科部。每个核心都由NEI资助的研究人员指导，并由高度专业的 合格和训练有素的系统经理，分析师和专家谁协助和培训视觉研究人员 使用最先进的资源。备有多种类型的先进设备，精良 软件和实践培训大大提高了研究成果的质量和数量 我们的Vision Core设施的用户。P30 Vision Cores具有：1）增加了严格的 使用临床相关和非侵入性成像模式的转化研究，2）生成协作 需要多个专业领域的项目，3）提高和增强现有研究的生产力 项目，从而使参与的调查员在争取资金方面保持竞争力，4）促进征聘 来自其他校区的新教师，和5）支持新的研究战略的发展， 使用PI无法获得的设备获取数据。向前看，三个 P30 Vision Cores将继续提供高水平的专业知识、仪器和服务， 提升我们对视觉科学研究前沿的贡献。

ABSTRACT Overall The goals of this P30 Vision Core Renewal Application are to manage and maintain existing and new core facilities that will provide expertise, technical support, equipment access, and personnel training for 24 independent vision research laboratories at the University of Oklahoma Health Sciences Center. We have had two highly utilized and successful cores: Live Animal Imaging and Functional Analysis Core (AAC) (which has been merged with the previous Genotyping Core), and a Cellular Imaging and Morphometric Analysis Core (CIC). In this competing renewal, we have added a new Ocular Immunobiology Core (OIC) to provide new equipment, training, and expertise for our rapidly growing interests in the immunological underpinnings of ocular diseases. The AAC (two independent modules) is conveniently located inside of the two major vivaria that house most of the vision research animals on campus, while the CIC and OIC are located in the Department of Ophthalmology. Each core is directed by an NEI-funded investigator and supervised by highly qualified and well-trained Systems Managers, Analysts, and Specialists who assist and train vision researchers in the use of state-of-the-art resources. The availability of multiple types of advanced equipment, sophisticated software, and hands-on training has dramatically increased the quality and quantity of research achievements by the users of our Vision Core facilities. The P30 Vision Cores have: 1) increased opportunities for rigorous translational research using clinically relevant and non-invasive imaging modalities, 2) generated collaborative projects that require multiple areas of expertise, 3) increased and enhanced productivity of existing research projects, thereby allowing participating investigators to remain competitive for funding, 4) promoted recruitment of new faculty from other campuses, and 5) supported the development of new research strategies based on the acquisition of data from the use of equipment otherwise unavailable to the PIs. Moving forward, the three P30 Vision Cores will continue to provide a high level of expertise, instrumentation, and service, further elevating our contributions to the forefront of vision science research.