Training Program in Lung Biology and Translational Medicine

摘要 阿拉巴马大学肺生物学和转化医学培训计划 伯明翰大学(UAB)在激励和协作的环境中提供多学科培训，培养 培养高能力和创新的生物医学研究科学家。该计划启动于 2010年培训肺部相关研究的医学博士或博士后研究员，目前已进入第10个年头，目前 每年分配6名实习生。在该计划的前10年，16/17(94%)已完成培训的学员 在研究密集型职业道路上的培训仍在继续，其中14/17人(80%)担任学术教职。 对拟议的培训采取多学科和转化性办法非常成功，而且 由30名教师导师组成的多样化和互动式小组重点介绍了他们的情况，他们在8名教师中担任主要预约 UAB科室(4-临床；4-研究)。教师导师分为三个主题领域，分别基于 在科学专长方面：(1)免疫学-微生物学；(2)细胞生物学-组织修复；(3)翻译科学。 统计遗传学、计算生物学、生物标记物发现和药物方面的翻译研究 发现/开发和临床试验将促进基础科学研究的临床转化(第1组 和2)。基于UAB的现有专业知识和正在进行的研究工作，培训将侧重于 肺部疾病的表现、诊断、风险/预后分层、机制、预防和治疗； 主要是急性肺损伤(ALI)、囊性纤维化(CF)、哮喘、慢性阻塞性肺疾病(COPD)以及 间质性肺疾病(ILD)。培训计划将高度个性化，并量身定做，以实现最大限度的成功 通过制定个人发展计划，对每个受训人员进行培训。除了研究项目外， 培训将在导师的实验室进行，培训将包括高度结构化的教学计划， 包括每周在肺、过敏和重症监护医学部举行的教学会议， 技能“课程(与亚利桑那大学博士后教育办公室合作)和研究核心 课程由T32培训学院教授，其中包括细胞可塑性等新兴主题， 人类免疫学、干细胞生物学、衰老、药物发现/开发、生物信息学和个性化 医药。正式的指导将包括负责任和合乎道德的研究行为，以及关于严谨的课程 以及研究的重现性。这项T32培训计划致力于“导师的指导”，员工队伍 多样性，并保持目前在学术生物医学研究职业生涯中学员的高留存率。

ABSTRACT The Training Program in Lung Biology and Translational Medicine at the University of Alabama at Birmingham (UAB) provides multidisciplinary training in a stimulating and collaborative environment that nurtures the development of highly competent and innovative biomedical research scientists. This Program, initiated in 2010 to train M.D. or Ph.D. postdoctoral fellows in lung-related research, is currently in its 10th year with a current allocation of 6 trainees/year. In the first 10 years of the Program, 16/17 (94%) of trainees who have completed training have continued in research-intensive career tracks, and 14/17 (>80%) hold academic faculty positions. The multidisciplinary and translational approach to the proposed training has been highly successful, and is highlighted by a diverse and interactive group of thirty faculty mentors who hold primary appointments in eight UAB Departments (4 – clinical; 4 – research). The faculty mentors are grouped into three thematic areas based on scientific expertise: (1) immunology-microbiology; (2) cell biology-tissue repair; (3) translational sciences. Translational research in statistical genetics, computational biology, biomarker discovery, and drug discovery/development and clinical trials will facilitate the clinical translation of basic science research (groups 1 and 2). Based on the existing expertise and ongoing research efforts at UAB, training will focus on the manifestations, diagnosis, risk/prognostic stratification, mechanisms, prevention, and treatment of lung diseases, primarily acute lung injury (ALI), cystic fibrosis (CF), asthma, chronic obstructive lung diseases (COPD), and interstitial lung diseases (ILD). Training programs will be highly individualized and tailored to maximize success of each trainee with the creation of individual development plans (IDPs). In addition to the research projects that will be conducted in the mentor’s laboratory, training will encompass a highly structured didactic program that includes weekly teaching conferences in the Division of Pulmonary, Allergy and Critical Care Medicine, a “survival skills” curriculum (in collaboration with the UAB Office of Postdoctoral Education) and a Research Core Curriculum, conducted by the T32 training faculty, that includes emerging themes such as cellular plasticity, human immunology, stem cell biology, aging, drug discovery/development, bioinformatics, and personalized medicine. Formal instruction will include the responsible and ethical conduct of research and a course on rigor and reproducibility in research. This T32 Training Program is committed to “mentoring of mentors”, workforce diversity, and maintaining the current high-rate of trainee retention in academic biomedical research careers.