Training in the Epidemiology of Aging

项目总结/摘要 这项关于继续竞争匹兹堡大学培训计划的建议， 自1989年以来，由NIA资助的老龄化流行病学主要集中在“老年人的流行病学”， 肌肉骨骼衰退和衰老中的残疾。”培训计划将包括3个预- 流行病学博士和2个博士后职位。我们丰富的多学科培训 环境是定制的每个学员的背景，以解决新的方法， 衰老研究，重点是尖端的生物和生理方法， 流行病学是公共卫生研究和实践的核心学科。我们的专业 职业发展的强大沟通和分析方法，导致学员 积极招聘到其他大学的博士后和教师职位， 政府和医疗保健。我们将继续培养下一代研究人员 通过指导，动手，多样化的研究经验，在老龄化流行病学的专业人士 有资金充足的领导人在该领域，和正式的课程。我们的目标的新重点包括：1） 应用衰老和长寿的生物学来研究正常和加速衰老相关的 关注肌肉、身体成分、移动性和残疾的生理变化; 骨质疏松症和骨关节炎;以及福尔斯和跌伤，用于与年龄有关的 2）发展老龄化的流行病学和定量统计方法 以传统技能为基础，强调最新技术的学习;以及 使用多学科和协作的方法来流行病学的专业领域的生物学 老龄化和长寿，卫生服务，多样性，健康公平和社会决定因素， 在确定积极工作的预期寿命和预防中年至晚年残疾的目标方面。到 培养学员技能，以领导教师发起的研究，我们将创建一个招聘和 测量核心我们在该领域有几项新的队列研究，包括 肌肉，流动性和衰老（SOMMA），一个前瞻性的，纵向队列的老年男性和 妇女获得肌肉组织样本，生物标志物和先进的肌肉成像有关， 另一项研究将这些肌肉表型与骨骼 来自高分辨率外周定量计算机断层扫描的参数。我们是一片田野 驯服研究中心，一项关于二甲双胍降低年龄相关多发病率的新随机试验， 功能衰退我们的培训计划是独一无二的准备使用我们现有的和新的研究 在临床试验和老龄化纵向队列研究中， 健康和身体功能，目的是防止老龄人口残疾。

Project Summary/Abstract This proposal for the competing continuation of the University of Pittsburgh Training Program in the epidemiology of aging, funded by the NIA since 1989, is focused on the “Epidemiology of Musculoskeletal Decline and Disability in Aging.” The training program will include 3 pre- doctoral and 2 post-doctoral positions in epidemiology. Our rich multidisciplinary training environment is customized to the background of each trainee to address novel approaches in aging research with an emphasis on cutting-edge biological and physiological methods for epidemiology, a core discipline for research and practice in public health. Our professional career development for strong communication and analytic methods, has resulted in trainees that are actively recruited to postdoctoral and faculty positions within other universities, the government, and health care. We will continue to train the next generation of research professionals in aging epidemiology through mentored, hands-on, diverse research experiences with well-funded leaders in the field, and formal courses. The new focus of our Aims includes: 1) To apply the biology of aging and longevity to study usual and accelerated age-related physiologic change with focus in Muscle, Body Composition, Mobility, and Disability; Osteoporosis and Osteoarthritis; and Falls and Fall Injuries, for the epidemiology of age-related functional decline; 2) To advance epidemiologic and quantitative statistical methods in aging studies with a foundation in traditional skills and emphasis on state-of-art techniques; and 3) To use a multidisciplinary and collaborative approach to epidemiology for specialty areas of Biology of Aging and Longevity, Health Services, and Diversity, Health Equity and Social Determinants, in defining targets for active life expectancy and prevention of disability from mid- to late life. To develop trainee skills to lead investigator-initiated studies, we will create a Recruitment and Measurement Core. We have several new cohort studies in the field including the Study of Muscle, Mobility and Aging (SOMMA), a prospective, longitudinal cohort of older men and women to obtain muscle tissue samples, biomarkers and advanced imaging of muscle related to risk of mobility disability and another study to relate to these muscle phenotypes with bone parameters from high resolution peripheral quantitative computed tomography. We are a field site for TAME, a new randomized trial of metformin for reducing age-related multi-morbidity and functional decline. Our training program is uniquely poised to use our existing and new research in clinical trials and longitudinal cohort studies of aging to elucidate pathways of musculoskeletal health and physical function, with the goal of preventing disability in the aging population.