2023 Excitatory Synapses and Brain Function Gordon Research Conference and Seminar

项目摘要 这项提案要求部分支持一个长期的，良好的参与，并深受戈登研究 2023年6月4日至9日在Les Diablerets会议上举行的兴奋性突触和脑功能会议（GRC） 中心在瑞士。在GRC之前，将举行戈登研究研讨会（GRS）， 研究生和博士后研究员于2023年6月3日至4日在同一地点。 兴奋性突触是使神经元之间的快速信号传输和通信成为可能的功能单位。 神经元通过这些连接，神经元建立起处理信息的功能回路， 产生所有的大脑功能。突触是目标 异常的突触功能与几种神经和精神疾病有因果关系，包括 许多常用的处方药， 精神分裂症、自闭症、抑郁症、药物成瘾、帕金森病、阿尔茨海默病、创伤性脑 因此，了解兴奋性突触的结构和功能 这不仅是推断脑功能知识的基础，也是寻找新的脑治疗策略的基础。 疾病会议将汇集不同学科的优秀初级和高级科学家 包括神经生物学家，解剖学家，分子和发育生物学家，生物化学家，细胞/分子生物学家， 影像学家、生物病理学家和神经生理学家， 受伤、中风和癫痫。 激发对当前概念的讨论 并为未来的研究确定新的挑战。该计划包括两个主题讲座和八个会议 它广泛地解决了突触回路解剖、学习和记忆过程、经验- 依赖性可塑性，技术进步，疾病的突触基础，NMDA受体结构和 功能，突触的规范和发展，从突触到基因和回来的信号。此外，海报 会议将允许所有与会者对这些专题作出贡献。 除了受邀演讲者外，我们还将从提交的摘要中选择年轻的科学家进行简短的口头演讲。 介绍。该计划的目的不仅是为了突出尖端的方法和刺激 在基础神经科学的合理生物学框架内的新概念、方法和技术， 也是为了促进科学界代表性不足的群体。这次会议将汇集专家科学家 在一个有利于讨论和交流思想的环境中，交流思想， 这次会议一直是该领域的推动力。我们期待2023年关于兴奋性突触的GRC， 脑功能将塑造未来的科学方向，并为NINDS的使命提供关键支持 与其他NIH研究所一样，如NIDA、NIMH、NICHD和NIA。

Project Summary This proposal requests partial support for a longstanding, well-attended, and well-received Gordon Research Conference (GRC) on Excitatory Synapses and Brain Function on June 4-9, 2023, at Les Diablerets Conference Center in Switzerland. The GRC will be preceded by a Gordon Research Seminar (GRS) targeted towards graduate students and postdoctoral fellows on June 3-4, 2023, at the same location. Excitatory synapses are functional units that enable rapid signal transmission and communication between neurons. Through these connections, neurons establish functional circuits that process information necessary to generate all brain functions. Synapses are the target aberrant synaptic function is causally linked to several neurological and psychiatric disorders, including of many commonly prescribed medications, and schizophrenia, autism, depression, drug addiction, Parkinson's disease, Alzheimer's disease, traumatic brain Understanding the structure and function of excitatory synapses is therefore fundamental not only to infer knowledge about brain function but also to find new therapeutic strategies for brain diseases. The conference will bring together outstanding junior and senior scientists across different disciplines including neuron biologists, anatomists, molecular and developmental biologists, biochemists, cell/molecular imagers, biophysicists and neurophysiologists with the goal of injury, stroke and epilepsy. stimulating discussions about current concepts and defining new challenges for future research. The program includes two keynote lectures and eight sessions that broadly address current issues in synaptic circuit dissection, learning and memory processes, experience- dependent plasticity, technological advances, synaptic basis of the diseases, NMDA receptor structure and function, synaptic specification and development, signaling from synapses to genes and back. In addition, poster sessions will permit all participants to contribute to these topics. Besides the invited speakers, we will select junior scientists from the submitted abstracts for short oral presentations. The program has been designed not only to highlight cutting edge approaches and to stimulate new concepts, methods and technologies within a sound biological framework of fundamental neuroscience, but also to promote underrepresented groups in science. The conference will bring together expert scientists worldwide in an environment that is conducive to discussion and exchange of ideas. The exchange of ideas at this conference has been a driving force for the field. We expect the 2023 GRC on Excitatory Synapses and Brain Function will shape future scientific directions and provide critical support for the mission of NINDS as well as other NIH institutes such as NIDA, NIMH, NICHD and NIA.