USC/UCLA Center for Biodemography and Population Health: Core B

抽象核心B 项目开发核心（PDC）的首要目标是提供试点资金，以支持 发展创新和突破性的研究，这将导致更充分地了解 影响老年人健康的过程，以及这些过程如何受到生物、 社会、行为、心理、经济、环境和卫生保健状况。先前的试点项目 大大增加了我们对生活环境、行为、压力源和 DNA遗传学影响生物学结果以及下游健康结果。项目也 在为随后的资助研究和重要出版物提供基础方面取得了极大的成功。在 为了与CBPH的总体目标保持一致，我们将一部分试点项目用于 发展生物和健康测量和数据方面的创新，提供更多的资源 为整个研究界。我们建议的第一年试点反映了CBPH目前的重点， 衰老的细胞和分子机制。试点1解决RNA转录组学和生命过程 主题;试点2解决背景，认知和表观遗传学/炎症主题;试点3解决细胞 衰老，DNA甲基化和生命历程;试点4解决认知和大脑老化的主题。他们都 建议使用至少一种新开发的数据：RNA转录组分析，DNA甲基化， 流式细胞术和MRI数据。PDC也是整合和发展的重要机制 生物人口学研究人员，包括新兴学者，新教师，教师过渡到 生物人口学在我们的大学和更广泛的领域。拟议的试点包括来自两个国家的研究人员， 其他大学和所有包括新兴学者。发展合作委员会与联合国 行政研究核心（ARC）和我们的研究资源和传播核心（RRDC）。最 试点项目产生的工作被纳入ARC组织的国家会议，一些试点项目要么开始， 过渡到RRDC中的验证项目。下一个周期的供资将进一步推动 生物人口学通过发展新的研究者，招募到该领域建立的高级研究者， 其他领域，并扩大人口健康研究中评估的生物参数范围， 目的是更清楚地了解生活经验影响的生物途径， 人口一级的健康和福祉轨迹，并解决各地区的重大健康差距 亚种群。

Abstract Core B The overarching aim of the Program Development Core (PDC) is to provide pilot funding to support the development of innovative and ground-breaking research that will lead to a fuller understanding of the processes affecting population health at older ages and how these processes are modified by biological, social, behavioral, psychological, economic, environmental, and health care conditions. Prior pilot projects have significantly increased our understanding of the roles of life circumstances, behaviors, stressors, and DNA genetics in affecting biological outcomes, as well as downstream health outcomes. Projects have also been extremely successful in providing a basis for subsequent funded research and significant publications. In keeping with the overarching aim of the CBPH, we have devoted a subset of our pilot projects to the development of innovations in biological and health measurement and data which provide increased resources for the entire research community. Our proposed pilots for the first year reflect the current CBPH focus on cellular and molecular mechanisms of aging. Pilot 1 addresses the RNA Transcriptomics and Life Course topics; Pilot 2 addresses the Context, Cognition and Epigenetics/Inflammation topic; Pilot 3 addresses the Cell Senesence, DNA Methylation & Life Course; Pilot 4 addresses the Cognition and Brain Aging topic. They all propose the use of at least one type of newly developed data: RNA transcriptome profiling, DNA methylation, flow cytometry, and MRI data. The PDC has also been an important mechanism for integrating and developing biodemographic researchers including emerging scholars, new faculty, and faculty transitioning into biodemography at both our Universities and in the wider field. Proposed pilots include researchers from two other Universities and all include an emerging scholar. The PDC is strongly integrated with the activities of the Administrative Research Core (ARC) and our Research Resource and Dissemination Core (RRDC). Most pilots produce work integrated into our national meetings organized by the ARC and some pilots either begin or transition to validation projects in the RRDC. Funding over the next cycle will further advance the field of Biodemography by developing new investigators, recruiting into the field established senior investigators from other fields, and broadening the range of biological parameters assessed in population health research, all with the aim of understanding more clearly the biological pathways through which lived experience impacts trajectories of health and wellbeing at the population level, and addressing critical health disparities across sub-populations.