Adaptive changes in HIV-1 subtype C envelope glycoproteins contributing to pathogenicity.

HIV有多种亚型。最常研究的是B型（B-HIV）。B-HIV在北美、欧洲和亚洲很常见，但仅占全球HIV感染的一小部分。非洲和亚洲的C型艾滋病毒（C-HIV）占全球感染的大多数，但对C-HIV如何导致艾滋病知之甚少。我们的目标是了解C-HIV如何导致艾滋病。这对于开发专门为最迫切需要的人设计的药物和疫苗至关重要。

HIV exists as multiple subtypes. The most commonly studied is type B (B-HIV). B-HIV is common in North America, Europe and Asia, but accounts for only a small fraction of HIV infections worldwide. Type C HIV (C-HIV) in Africa and Asia accounts for the majority of infections worldwide, yet very little is known about how C-HIV causes AIDS. We aim to understand how C-HIV causes AIDS. This is critical for development of drugs and vaccines specifically designed for those who are most urgently need.