CSHL Cancer Center Support Grant

总体--摘要 冷泉港实验室(CSHL)癌症中心是一家卓越的基础癌症研究机构。 50多年前，专注于战略的努力研究了人类癌症的遗传学，奠定了 为今天的多重突破奠定了基础。因此，CSHL癌症中心的研究人员已经做出了 关于肿瘤如何启动和发展的发现，他们产生了新的工具、方法和 世界各地使用的癌症模型。 在过去的五年里，CSHL癌症中心的领导层在David Tuveson的领导下顺利交接 承担中心主任的角色。图弗森大大扩充了癌症中心的领导团队， 重组了计划和共享资源，并添加了新的研究基础设施以支持新的 倡议，并保持该中心的高度协作和综合研究。CSHL癌症中心 现在有43个正式成员，他们分为三个研究项目：癌症遗传学和基因组学； 基因调控和遗传；以及癌症中的细胞通讯。这些节目中的研究 由10个共享资源提供支助，这些资源提供获取尖端技术和专门知识的途径。 这一转变推动了癌症中心的卓越研究。总体而言，癌症中心专注于 三大主题：定义癌症发生和发展的基本分子机制 进展；确定驱动肿瘤发生的肿瘤和间质细胞异质性的特征； 以及开发新的实验和计算技术，以帮助癌症诊断和治疗。 在这个资助周期中，中心成员发表了408篇与癌症相关的研究论文，其中41%发表在期刊上 影响因子大于10。癌症中心成员因其重大贡献而受到表彰 在这一资助期间，科学获得了43个竞争激烈的国家和国际奖项。巨蟹座 中心继续高度协作，27%的出版物代表了AT之间的协作 至少两名中心成员。最后，为了支持这些努力，成员们获得了1180万美元的 与癌症相关的、经过同行评审的资金。 在下一个资助期，癌症中心将继续利用 基础研究。与此同时，癌症中心致力于增加与癌症患者和 患者衍生模型，便于扩展到人类生物学和临床翻译。来自癌症基金会的资金 中心支持赠款将支持癌症中心的领导、管理、教育和培训， 促进创新科学的发展基金，以及提供必要资源的共享资源 推动我们癌症研究的技术。

OVERALL – ABSTRACT The Cold Spring Harbor Laboratory (CSHL) Cancer Center is a preeminent institute for basic cancer research. More than 50 years ago, strategically focused efforts investigated the genetics of human cancer, laying the foundation for multiple breakthroughs today. As a result, researchers in the CSHL Cancer Center have made discoveries about how tumors initiate and progress, and they have produced novel tools, approaches, and cancer models that are used around the world. Over the last five years, the leadership of the CSHL Cancer Center transitioned smoothly, with David Tuveson assuming the role of Center Director. Tuveson substantially expanded the Cancer Center leadership team, reorganized the Programs and Shared Resources, and added new research infrastructure to support new initiatives and maintain the highly collaborative and integrated research in the Center. The CSHL Cancer Center now has 43 full members, who are divided into three research programs: Cancer Genetics and Genomics; Gene Regulation and Inheritance; and Cellular Communication in Cancer. The research in these Programs is supported by 10 Shared Resources, which provide access to cutting-edge technologies and expertise. This transition has propelled the Cancer Center’s research excellence. Broadly, the Cancer Center focuses on three major themes: defining the basic molecular mechanisms underpinning cancer development and progression; determining the features of neoplastic and stromal cellular heterogeneity that drive tumorigenesis; and developing novel experimental and computational technologies to assist cancer diagnosis and therapy. Center members published 408 cancer-relevant research papers during this funding cycle, with 41% in journals with an impact factor greater than 10. Cancer Center members were recognized for their significant contributions to science with 43 highly competitive national and international awards during this funding period. The Cancer Center continues to be highly collaborative, with 27% of publications representing a collaboration between at least two Center members. And finally, to support these efforts, members have obtained $11.8 million dollars in cancer-relevant, peer-reviewed funding. In the next funding period, the Cancer Center will continue to make foundational discoveries about cancer using basic research. At the same time, the Cancer Center is committed to increasing links to cancer patients and patient-derived models to facilitate an extension to human biology and clinical translation. Funds from the Cancer Center Support Grant will support the Cancer Center Leadership, Administration, Education and Training, the Developmental Funds that enhance innovative science, and the Shared Resources that provide essential technologies to advance our cancer research.