Methods Core

抽象方法核心 Apires方法核心(MC)将来自不同和互补背景的研究人员聚集在一起 共同应对阻碍设计、实施、方法和技术方面的挑战 在有效降低青年自杀率方面取得进展。我们的跨学科团队包括以下领域的专家 用于行为和人群干预、预测性分析以改善临床的研究设计方法 决策、数字卫生干预措施的发展、实施科学、定性方法、 集成代表患者和社区健康的多级别数据元素，以及地理空间 环境和社会结构对人口健康的影响模型。MC利用大量的 阿比盖尔·韦克斯纳研究所(AWRI)的机构基础设施和智力资本 全国儿童医院(NCH)和俄亥俄州立大学(OSU)，以及共同领导布罗克博士， McAlearney和Lin分别领导过专业和多学科团队，具有广泛的影响力 多个健康领域。MC将与ASILES调查人员合作，促进儿科人口1) 开发和测试新的、可扩展的干预措施和研究产生的资源， 对利益攸关方的呼吁；2)迅速和广泛传播新的有效做法；3)持续 改进现实环境中提供的自杀预防干预措施；4)跨学科团队 科学促进针对棘手的自杀预防挑战的新的和融合的解决方案；以及5)培训 来自不同背景的学生、研究员、早期职业生涯和高级调查人员，以增加 进行尖端转化式自杀预防研究的研究人员的多样性。我们的MC提供了一个 方法锚连接所有渴望的项目，我们的跨学科团队具有实质性的 NCH和OSU的专业知识、资源和基础设施将确保所有渴望的项目 以科学严谨的方式进行，并广泛传播。与零自杀研究所建立创造性的伙伴关系 俄亥俄州立大学CCTS试点项目计划加强了外展、参与和传播。方法论 和我们MC的技术进步为克服面临的挑战提供了创新的方法 降低青少年自杀率的行为干预。协同研究设计要素 Apires项目提供了独特的机会来研究自杀的实施和疗效方面 初级护理、专科护理和急性护理的预防干预。总体而言，这些事态发展支持 对Apires干预措施进行创新和严格的评估，并为进一步设计提供基础 以及完善必要的实施战略，以便在今后的研究中扩大这些干预措施的规模。

ABSTRACT – METHODS CORE The ASPIRES Methods Core (MC) brings together investigators from diverse and complementary backgrounds to collectively address design, implementation, methodological, and technological challenges that impede progress toward effectively reducing the youth suicide rate. Our transdisciplinary team includes experts in study design methodology for behavioral and population interventions, predictive analytics to improve clinical decision making, development of digital health interventions, implementation science, qualitative methods, integration of multi-level data elements representative of patient and community health, and geospatial modeling of environment and social structure on population health. The MC capitalizes on substantial institutional infrastructure and intellectual capital at both The Abigail Wexner Research Institute (AWRI) at Nationwide Children’s Hospital (NCH) and The Ohio State University (OSU), and Co-Leaders Drs. Brock, McAlearney, and Lin have each led both specialized and multidisciplinary teams with broad impact spanning multiple areas of health. The MC will work with ASPIRES investigators to facilitate in a pediatric population 1) development and testing of novel and scalable interventions and research-generated resources with significant appeal for stakeholders; 2) rapid and widespread dissemination of new, effective practices; 3) continuous improvement of suicide prevention interventions delivered in real-world settings; 4) interdisciplinary team science to facilitate novel and convergent solutions to intractable suicide prevention challenges; and 5) training of students, fellows, early career, and advanced investigators from diverse backgrounds to increase the diversity of investigators conducting cutting-edge translational suicide prevention research. Our MC provides a methodological anchor connecting all ASPIRES projects, and our transdisciplinary team with substantial expertise, resources, and infrastructure at both NCH and OSU will ensure that all ASPIRES projects are conducted with scientific rigor and broadly disseminated. Creative partnerships with the Zero Suicide Institute and the OSU CCTS Pilot Project Program augment outreach, engagement, and dissemination. Methodological and technological advances from our MC provide innovative approaches to overcoming challenges facing behavioral interventions for reducing the youth suicide rate. Synergistic study design elements across ASPIRES projects provide unique opportunities to study implementation and efficacy aspects of suicide prevention interventions across primary, specialty, and acute care. Collectively, these developments support innovative and rigorous evaluation of ASPIRES interventions and provide the groundwork for further design and refinement of implementation strategies necessary to scale these interventions in future studies.