Program in Hematology: Molecular & Cell Biology of Blood Cells

项目摘要 这重新提交申请要求继续资助博士后研究培训计划， 血液学已经成功地吸引了年轻的科学家和医生，科学家进入学术 血液学和血管生物学的职业生涯。该计划的主要目标是准备MD， MD/PhD和PhD博士后研究员，作为学术科学家和医生的生产性职业- 科学家该补助金支持的培训重点仍然是核心科学学科， 血液学我们要求每年支持四名博士后培训生（两名博士生和两名博士生）。 MD或MD/PhD学员），这与上一个赠款期相同。培训将在 在一个活跃的基础，转化和临床研究的机构， 强调职业发展和协作科学。具体目标是：（1）识别 并招募不同性别，种族和文化的优秀博士后学员，他们希望获得 对基础和转化研究的原理和技术的全面了解， 血液学、血细胞、血管生物学、凝血、造血和免疫生物学;（2）吸引 高度积极的科学家和医生科学家，并为他们提供全面的指导， 设计和实施高质量的研究项目，包括参与跨学科研究 （3）培养医学科学家从事血液学和相关科学的学术事业 纪律，并为他们成功过渡到独立调查人员做好准备;以及（4）揭露 有才华的博士科学家血液学领域，并培养他们的职业生涯作为独立的研究人员 和研究科学家。自上一次更新以来，已经采取了几项新的举措。课程 现在包括临床血液学的核心讲座和血液学研究方法的必要研讨会， 严谨性和可重复性，以及授权写作。指导委员会和个人发展计划是 要求所有学员。自2000年以来，已经为医生科学家制定了一个结构化的指导计划。 以前提交的。培训的基础继续以受指导的个人为中心 研究项目，其特点是在一个既定的， 敬业的导师教学式和辅导式培训补充和加强了这一培训 在团队科学和转化科学的机会，并通过接触生产调查 在相关领域工作，包括在基础生物医学科学、基因组学、 计算生物学和生物信息学。多样化的教师提供的丰富的培训环境， 广泛的实验室、临床和核心设施，以及强有力的机构支持，应确保 成功地吸引和培养高素质的博士后学员从事学术工作 血液学

PROJECT SUMMARY This resubmission application requests continued funding for a postdoctoral research training program in hematology that has been successful in attracting young scientists and physician-scientists into academic careers in hematology and vascular biology. The program has as its primary objective to prepare MD, MD/PhD, and PhD postdoctoral fellows for productive careers as academic scientists and physician- scientists. The focus of training supported by this grant remains within the core scientific discipline of hematology. We are requesting support for four postdoctoral trainees per year (two PhD trainees and two MD or MD/PhD trainees), which is unchanged from the previous grant period. The training will be carried out in an enriched environment of active basic, translational and clinical investigation at an institution that emphasizes the career development and collaborative science. The specific objectives are: (1) To identify and recruit outstanding postdoctoral trainees, of diverse gender, ethnicity and culture, who wish to obtain comprehensive knowledge of the principles and techniques of basic and translational research related to hematology, blood cells, vascular biology, coagulation, hematopoiesis, and immunobiology; (2) To attract highly motivated scientists and physician-scientists and provide them with comprehensive instruction in the design and implementation of high quality research projects, including participation in cross-disciplinary research teams; (3) To train physician-scientists for academic careers in hematology and related scientific disciplines and prepare them for successful transition to independent investigators; and (4) To expose talented PhD scientists to the field of hematology and train them for careers as independent investigators and research scientists. Since the last renewal, several new initiatives have been instituted. The curriculum now includes core lectures in clinical hematology and required workshops in hematology research methods, rigor and reproducibility, and grant writing. Mentoring committees and individual development plans are required for all trainees. A structured mentoring plan for physician scientists has been developed since the previous submission. The foundation of training continues to be centered on the individual mentored research project, marked by a period of intensive, sustained research under the guidance of an established, dedicated mentor. This training is supplemented and enhanced by didactic and mentored training opportunities in team science and translational science, and by exposure to productive investigators working in related areas, including scientists with expertise in basic biomedical science, genomics, computational biology, and bioinformatics. The rich training environment provided by the diverse faculty, extensive laboratory, clinical, and core facilities, and strong institutional support should ensure continued success in attracting and preparing highly qualified postdoctoral trainees for careers in academic hematology.