Biostatistics and Data Science Core

摘要/摘要 波士顿OAIC计划需要在实验设计、生物统计学和数据科学方面的不同专业知识 使严谨和可重复的研究能够在不同的实验环境中成功实施 人口。为了满足这些需要，我们在这里建议继续和一些扩展波士顿 OAIC多产且成功的生物统计设计和分析核心。与核心保持一致 统计方法和当代分析以及研究软件方面的互补重点 该资源已更名为生物统计和数据科学核心(BDSC)。 BDSC的总体目标是向OAIC项目提供生物统计和数据管理支持； 与OAIC调查人员合作并向其提供咨询；为以下人员提供指导和培训 研究教育部分(REC)和试点和探索科学核心(PESC)奖获得者；以及 开展新的统计和数据科学研究。 BDSC的具体目标是： 目标1.通过提供生物统计和数据管理，与伊斯兰会议组织的调查人员和受训人员合作 对OAIC项目的支持 目标2.为REC和PESC获奖者提供研究设计和数据分析方面的严格培训，以及 目标3.开发和传播新的量化方法以及数据科学和生物信息学工具 与伊斯兰会议组织的项目和优先事项保持一致 AIM 1建立在BDSC教职员工和OAIC调查人员之间非常成功的合作基础上， 在前几个周期的150多份出版物中得到了反映。目标2在我们现有的基础上构建和扩展 生物统计和数据科学课程，是在当前周期内开发的，目前正在经历 修订和改进，并专门为提供量化科学教育而量身定做 量化科学家和相关的临床研究人员在老龄化。目标3扩展了我们目前的努力，包括 在生存分析、实用临床试验、寿命和统计方面的新统计方法的发展 遗传学；以及现在广泛使用的新软件、再生性和信息学工具的开发 在生物医学和波士顿OAIC社区。 综合起来，这些目标将使BDSC能够以成本效益的方式支持OAIC的研究和培训 首创精神。以前周期的生产率证明了拟议的核心对OAIC的整体影响 这项工作取得了成功，并强调了继续开展这项工作对波士顿伊斯兰会议组织使命的潜在价值。

SUMMARY/ABSTRACT The Boston OAIC programs require diverse expertise in experimental design, biostatistics, and data science to enable successful implementation of rigorous and reproducible research in diverse experimental settings and populations. To address these needs, we here propose the continuation and some expansion of the Boston OAIC’s productive and successful Biostatistical Design and Analysis Core. In keeping with the Core’s complementary foci in statistical methodology and in contemporary analytics, and research software development, this resource has been renamed the Biostatistics and Data Science Core (BDSC). The overall goals of the BDSC are to provide biostatistical and data management support to OAIC projects; collaborate with and provide consultation to OAIC investigators; to provide mentorship and training to Research Education Component (REC) and Pilot and Exploratory Science Core (PESC) awardees; and to conduct novel statistics and data science research. The BDSC’s Specific Aims are: Aim 1. To collaborate with OAIC investigators and trainees by providing biostatistical and data management support to OAIC projects Aim 2. To provide rigorous training in research design and data analysis for REC and PESC awardees, and Aim 3. To develop and disseminate novel quantitative methods and data science and bioinformatics tools aligned with the OAIC projects and priorities Aim 1 builds upon the highly successful collaborations between the BDSC's faculty and the OAIC investigators, reflected in more than 150 publications in the prior cycles. Aim 2 builds upon and extends our existing biostatistical and data science curriculum, developed during the current cycle which is undergoing continuous revision and improvement, and which is specifically tailored to provide quantitative science education both to quantitative scientists and to allied clinical researchers in aging. Aim 3 extends our current efforts both in the development of novel statistical methods in survival analysis, pragmatic clinical trials, longevity, and statistical genetics; and in the development of novel software, reproducibility, and informatics tools now in extensive use in the biomedical and Boston OAIC communities. Together these aims will enable the BDSC to cost-effectively support the OAIC's research and training initiatives. The productivity of prior cycles attests to the impact of the proposed Core on the OAIC's overall success and underscores the potential value of its continuation to the Boston OAIC's mission.