Biostatistics and Data Science Core

生物统计学和数据科学核心

• 批准号: 10470358
• 负责人: Thomas Glenn Travison
• 金额: $ 24.6万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10470358
• 关键词: Address; Aging; American; Architecture; Area; Biometry; Biostatistics Core; Boston; Capsicum; Clinical; Cognition; Collaborations; Computer software; Consultations; Data; Data Analyses; Data Science; Data Science Core; Development; Educational Activities; Educational Curriculum; Elderly; Experimental Designs; Faculty; Funding; Genetic; Goals; Industry Standard; International; Longevity; Measurement; Measures; Medical History; Mentorship; Methodology; Methods; Mission; Monitor; Population; Pragmatic clinical trial; Productivity; Publications; Publishing; Reporting; Reproducibility; Research; Research Design; Research Personnel; Research Training; Resources; Science; Scientist; Software Tools; Statistical Methods; Survival Analysis; System; Time; Training; Training Activity; Training Programs; Work; academic standard; bioinformatics tool; community center; cost; data management; design; education research; implantable device; improved; informatics tool; innovation; instrument; meetings; novel; prevent; programs; science education; software development; software repository; statistics; success; tool; tool development; translational approach; wearable device

SUMMARY/ABSTRACT The Boston OAIC programs require diverse expertise in experimental design, biostatistics, and data science to enable successful implementation of rigorous and reproducible research in diverse experimental settings and populations. To address these needs, we here propose the continuation and some expansion of the Boston OAIC’s productive and successful Biostatistical Design and Analysis Core. In keeping with the Core’s complementary foci in statistical methodology and in contemporary analytics, and research software development, this resource has been renamed the Biostatistics and Data Science Core (BDSC). The overall goals of the BDSC are to provide biostatistical and data management support to OAIC projects; collaborate with and provide consultation to OAIC investigators; to provide mentorship and training to Research Education Component (REC) and Pilot and Exploratory Science Core (PESC) awardees; and to conduct novel statistics and data science research. The BDSC’s Specific Aims are: Aim 1. To collaborate with OAIC investigators and trainees by providing biostatistical and data management support to OAIC projects Aim 2. To provide rigorous training in research design and data analysis for REC and PESC awardees, and Aim 3. To develop and disseminate novel quantitative methods and data science and bioinformatics tools aligned with the OAIC projects and priorities Aim 1 builds upon the highly successful collaborations between the BDSC's faculty and the OAIC investigators, reflected in more than 150 publications in the prior cycles. Aim 2 builds upon and extends our existing biostatistical and data science curriculum, developed during the current cycle which is undergoing continuous revision and improvement, and which is specifically tailored to provide quantitative science education both to quantitative scientists and to allied clinical researchers in aging. Aim 3 extends our current efforts both in the development of novel statistical methods in survival analysis, pragmatic clinical trials, longevity, and statistical genetics; and in the development of novel software, reproducibility, and informatics tools now in extensive use in the biomedical and Boston OAIC communities. Together these aims will enable the BDSC to cost-effectively support the OAIC's research and training initiatives. The productivity of prior cycles attests to the impact of the proposed Core on the OAIC's overall success and underscores the potential value of its continuation to the Boston OAIC's mission.

总结/摘要 波士顿OAIC计划需要实验设计，生物统计学和数据科学方面的各种专业知识， 在不同的实验环境中成功实施严格和可重复的研究， 人口。为了满足这些需求，我们在这里建议继续和一些扩展波士顿 OAIC的生产力和成功的生物统计设计和分析核心。为了与核心保持一致 在统计方法和当代分析和研究软件的互补焦点 在开发过程中，该资源已更名为生物统计学和数据科学核心（BDSC）。 生物统计和数据中心的总体目标是向审计和调查办公室的项目提供生物统计和数据管理支助; 与OAIC调查人员合作并提供咨询;为以下人员提供指导和培训： 研究教育部分（REC）和试点和探索性科学核心（PESC）获奖者;以及 进行新的统计和数据科学研究。 BDSC的具体目标是： 目标1.通过提供生物统计和数据管理，与OAIC研究者和学员合作 对审调处项目的支助 目标2.为REC和PESC获奖者提供研究设计和数据分析方面的严格培训， 目标3。开发和传播新的定量方法、数据科学和生物信息学工具 与国际审计和调查办公室的项目和优先事项保持一致 目标1建立在BDSC的教师和OAIC调查人员之间非常成功的合作基础上， 这反映在前几个周期的150多份出版物中。目标2建立并扩展了我们现有的 生物统计和数据科学课程，在本周期内开发，目前正在进行持续的 修订和改进，并专门为提供定量科学教育， 定量科学家和老龄化方面的临床研究人员。目标3扩大了我们目前在以下两个方面的努力： 在生存分析、实用临床试验、寿命和统计学方面开发新的统计方法 遗传学;以及现在广泛使用的新软件，再现性和信息学工具的开发 在生物医学和波士顿OAIC社区。 这些目标将使BDSC能够以具有成本效益的方式支持OAIC的研究和培训 举措先前周期的生产力证明了拟议的核心对OAIC总体 成功，并强调其继续波士顿OAIC的使命的潜在价值。