Midwest Roybal Center for Health Promotion and Translation

试点核心摘要 我们的试点核心将确定有才华的调查人员，并为他们提供指导，支持和激励， 将使他们能够测试具有高度可扩展性的干预措施，并有能力在我们的科学中推进科学。 专题重点领域。此更新应用程序针对四个重点主题领域：身体活动（PA） 推广，新的干预措施，将保持或提高个人的流动性，利用技术， 促进健康老龄化和持续的行为改变。 这个试点核心描述了两个拟议的第一年试点项目，将由我们的Roybal更新 中心以及第2年和后续试点，符合并将使我们能够实现 上述总体使命。这些试点项目将推动科学知识的发展， 体育活动（PA）和PA干预同时影响 移动性和认知能力。拟议的试点项目还将技术纳入其干预设计， 提高保真度和可伸缩性，并嵌入行为改变机制， 坚持PA。 一年级的Bronas飞行员建议利用行为决定的互动效应来打断和 在ADRD高风险的老年拉丁美洲人中，使用生态学方法用PA替代久坐行为 瞬时干预将通过生态瞬时评估方法进行测试。第一年Bhatt 一个试点项目旨在研究PA和认知训练相结合的可行性和有效性（CogXergaming） 用于改善运动平衡控制、认知、肌肉质量和心血管 健身;所有这些都将导致增加PA，社区流动性和改善与健康相关的生活质量。 第一年的两个试点项目将使用我们新的多模式ADRD获得参与者子样本的成像数据 成像和连接组学核心。该核心将协助研究者招募受试者，使用 检查ADRD结局的统一数据集，并酌情协助成像，包括 管理、存储和分析成像数据。这些飞行员和其他类似飞行员的累积效应 将是在科学和实践方面取得实质性进展， PA中的老年人群体，并提高了对PA、流动性 和大脑健康。总的来说，这些干预措施预计将有助于提高生活质量， 在地方、区域和国家范围内促进老年人的独立功能。

Pilot Core Abstract Our Pilot Core will identify talented investigators and provide them with mentoring, support, and incentives that will enable them to test interventions that are highly scalable and have the capacity to advance science in our areas of thematic focus. This renewal application targets four thematic areas of focus: physical activity (PA) promotion, novel interventions that will maintain or enhance mobility in individuals, harnessing technology to promote healthy aging, and sustaining behavior change. This Pilot Core describes two proposed Year 1 pilot projects that will be undertaken by our Roybal renewal Center as well as Year 2 and subsequent pilots that are consistent with and will enable us to achieve the overall mission described above. These pilots will advance scientific knowledge in the engagement of understudied populations in physical activity (PA) and the ability of PA interventions to simultaneously affect mobility and cognition. The proposed pilots also incorporate technology into their intervention designs to increase fidelity and scalability and embed mechanisms of behavior change that will promote long-term adherence to PA. The Year 1 Bronas pilot proposes to harness the interactive effects of behavior determination to interrupt and replace sedentary behavior with bouts of PA in older Latinos at high risk for ADRD using an Ecological Momentary Intervention that will be tested with Ecological Momentary Assessment methods. The Year 1 Bhatt pilot seeks to examine the feasibility and effectiveness of combined PA and cognitive training (CogXergaming) in frail older adults for improving locomotor-balance control, cognition, muscle quality, and cardiovascular fitness; all of which will lead to increased PA, community mobility, and improved health-related quality of life. Both Year 1 pilots will obtain imaging data on a subsample of participants using our new Multimodal ADRD Imaging and Connectomics Core. This Core will assist investigators with participant recruitment, use of a uniform dataset to examine ADRD outcomes, and assistance with imaging as appropriate, including the management, storage and analysis of imaging data. The cumulative effects of these pilots and others like them will be substantial advances in science and practice concerning the engagement of understudied minority populations of older adults in PA and improved understanding about the interconnections between PA, mobility and brain health. Collectively, these interventions are expected to contribute to enhanced quality of life and independent functioning among older adults locally, regionally, and nationally.