Drinking Water Arsenic, Blood Pressure, and Ischemic Stroke in the REGARDS Study

摘要 这个高度跨学科的项目的目标是利用流行病学，水文学和生物统计学 利用空间数据链接将饮用水砷数据（或模型预测）与 卒中的地理和种族差异的原因中的心脏代谢健康结果 学习。REGARDS研究是一项双胞胎（非裔美国人和白色人）队列研究， 从美国各地招募，重点是美国东南部。大样本 这一群体的大小和地理变化使其成为空间饮用水砷的理想来源 流行病学这项拟议的工作将支持开发和完善一种新的数据分析 管道，这将允许集成多个数据流（社区供水系统公共供水 质量数据，以及与私人威尔斯相关的地下水预测）， 饮用水砷和心脏代谢健康结果。这项研究的主要结果是血液 REGARDS研究基线访视时的血压，REGARDS研究基线时的高血压患病率 REGARDS研究中有缺血性卒中事件风险的参与者中的缺血性卒中事件 基线中风。本研究将根据假定的砷浓度， 效果调节剂（例如，性别、种族）。成功完成项目目标不仅将解决重大问题， 美国关于饮用水砷对心脏代谢健康的潜在显著性的知识差距 美国，而且还提供了一个高度创新的数据分析管道，可以成为未来饮酒的基础 美国的水健康研究。

ABSTRACT The goal of this highly interdisciplinary project, which draws on epidemiological, hydrological, and biostatistical expertise, is to use spatial data linkage to connect drinking water arsenic data (or model predictions) to cardiometabolic health outcomes in the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study. The REGARDS Study is a biracial (African American and white) cohort with participants recruited from across the United States, with emphasis on the Southeastern United States. The large sample size and geographic variation in this cohort make it an ideal resource for spatial drinking water arsenic epidemiology. This proposed work will support the development and refinement of a novel data analytic pipeline, which will allow integration of multiple data streams (community water system public supply water quality data, and groundwater predictions relevant for private wells) to give epidemiological inferences about drinking water arsenic and cardiometabolic health outcomes. The primary outcomes of the study are blood pressure at the REGARDS Study baseline visit, hypertension prevalence at the REGARDS Study baseline visit, and incident ischemic stroke among participants in the REGARDS Study at risk of incident ischemic stroke at baseline. The study will consider potential differences in response to arsenic according to putative effect modifiers (e.g., sex, race). Successful completion of the project aims will not only address significant knowledge gaps about drinking water arsenic’s potential salience to cardiometabolic health in the United States, but also provide a highly innovative data analysis pipeline that can be the foundation for future drinking water health research in the United States.