Eunice Kennedy Shriver NICHD Cooperative Multicenter Neonatal ResearchNetwork

新墨西哥州大学在新生儿研究方面有着杰出的贡献记录。 网络我们的团队作为主要研究者领导了包括氢化可的松在内的试验， BPD，达贝泊用于早产儿的神经保护，以及一项观察性和干预性研究， 足月儿心血管功能不全。杰西麦克斯韦博士开发了一种新的实验室测定法， Darbepopolysine用于DARBE研究。我们支持我们的初级研究人员，包括神经病学研究员， 向网络提出研究建议。随着麦克斯韦博士作为本申请的合作研究者的加入，我们 将继续发展我们的领导力。她是IDEA州儿科临床研究所的初级研究员， UNM的临床试验网络（ISPCTN），ACT NOWS研究的研究中心PI，并已批准ISPCTN初步研究。博士 Fuller在今年早些时候担任了PI的角色，在我们前进的过程中提供领导; Watterberg博士将继续留任 作为候补PI，提供连续性随访是UNM的标志性优势，无论是临床还是结局 research.这是通过Lowe博士，Fuller博士和Watterberg博士之间的密切合作而实现的。劳医生 在母婴互动、行为结果和执行功能方面， 评估，和NRN贝利黄金标准考官。我们的团队已经发布了创建一个 语言中立的发展评估，并了解语言对发展的影响 试验. Lowe博士对早期工作记忆的研究是一种语言中立的早期发展措施， 作为6-7岁时语言和处理技能的重要预测因素， 新生儿结局文献。Watterberg博士获得了NHLBI的资金来研究肾上腺功能， SUPPORT NEURO学龄期随访队列中6岁时的心血管结局。然后是Lowe医生 率先对这一队列中的行为结果以及这些结果之间的关系进行了额外的研究。 皮质醇觉醒反应的结果。我们期望继续为取得成果作出重大贡献 在下一轮的研究中。新墨西哥州是一个“少数族裔占多数”的州，48%的西班牙裔和9%的 美洲原住民，西班牙裔人口比例最高，仅次于阿拉斯加州 为美洲原住民服务我们的人口在NRN中是独一无二的，因为它有很高的西班牙裔和土著入学率。 美国人，我们的通用数据库新生儿中有52%是西班牙裔，23%是美洲原住民， 2006年，29 - 68%的西班牙裔婴儿和27 - 50%的美洲土著婴儿在同意的研究中。我们的记录 贡献，我们在成果研究方面的具体专业知识，以及我们独特的人口，使UNM成为 NRN的杰出候选人。

The University of New Mexico has an outstanding track record of contributions to the Neonatal Research Network. Our team has provided leadership as Principal Investigators for trials including Hydrocortisone for BPD, Darbepoetin for Neuroprotection in Preterm Infants, and both an observational and interventional study of cardiovascular insufficiency in term infants. Dr. Jessie Maxwell developed a novel laboratory assay for darbepoetin for the DARBE study. We have supported our junior investigators, including neonatology fellows, in proposing studies to the network. With the addition of Dr. Maxwell as a co-investigator in this application, we will continue to develop our leadership. She is the junior investigator for the IDeA States Pediatric Clinical Trials Network (ISPCTN) at UNM, site PI for ACT NOWS studies and has an approved ISPCTN pilot study. Dr. Fuller took on the role of PI earlier this year, providing leadership as we go forward; Dr. Watterberg will remain as Alternate PI, providing continuity. Follow-up is a signature strength for UNM, both clinically and in outcomes research. This is made possible by the close collaboration among Drs. Lowe, Fuller, and Watterberg. Dr. Lowe is a well-established researcher in maternal-infant interactions, behavioral outcomes, and executive function evaluation, and an NRN Bayley Gold Standard examiner. Our team has published efforts to create a language-neutral developmental assessment and to understand the impact of language on developmental testing. Dr. Lowe’s studies of early working memory as a language-neutral measure of early development and as a significant predictor of verbal and processing skills at 6-7 years have been important contributions to the neonatal outcome literature. Dr. Watterberg obtained NHLBI funding to study adrenal function and cardiovascular outcomes at age 6 years in the SUPPORT NEURO school-age follow-up cohort. Dr. Lowe then spearheaded additional investigations of behavioral outcomes in this cohort and the relationship of these outcomes to cortisol awakening response. We expect to continue our significant contributions to outcomes research during the next grant cycle. New Mexico is a ‘minority majority’ state, with 48% Hispanic and 9% Native American individuals, the highest percentage of Hispanic individuals of any state and second to Alaska for Native Americans. Our population is unique in the NRN for its high enrollment of Hispanic and Native Americans, with 52% of our Generic Database newborns being Hispanic and 23% Native American since 2006, and 29 – 68% Hispanic and 27 – 50% Native American infants in consented studies. Our record of contributions, our specific expertise in outcomes research, and our unique population make UNM an exceptional candidate for the NRN.