Biostatistics and Data Management Resource Core

修改项目摘要/摘要部分 生物统计学和数据管理（BDM）核心将在国际URBAN酒精研究合作艾滋病毒/艾滋病（URBAN酒精）中心发挥关键作用，作为研究设计，实施，数据管理和统计分析的全面合作者。BDM核心的总体目标是促进长期进行严格的，可重复的和创新的酒精/艾滋病毒研究。在接下来的五年里，BDM核心将与国际城市卫生中心的研究人员密切合作，为两个研究项目提供统计专业知识和有效的数据管理，这两个项目的重点是了解酒精使用对结核病感染、活动性疾病、艾滋病毒感染者在接受结核病治疗后患上结核病和肺部疾病以加速未来干预措施的发展，减少酒精对艾滋病毒携带者结核病相关发病率和死亡率的影响。BDM核心将在研究的所有阶段提供统计和数据管理领导，以确保数据质量和统计分析的高标准。BDM核心汇集了一支经验丰富的研究人员团队，他们具有独特的资格来支持国际URBAN ARCH中心，因为他们对与酒精、艾滋病毒和结核病相关的基础科学和临床问题拥有广泛的知识，并且与URBAN ARCH研究人员有着悠久的富有成效的合作历史。拥有这个专用的BDM核心将增强研究人员的协同作用和生产力，促进科学发现的有效性和普遍性，促进数据共享，并最终提高对酒精对PLWH中结核病感染谱的影响的理解。

Modified Project Summary/Abstract Section The Biostatistics and Data Management (BDM) Core will play a pivotal role in the International URBAN Alcohol Research Collaboration on HIV/AIDS (URBAN ARCH) Center as a full collaborator in study design, conduct, data management and statistical analyses. The overarching goal of the BDM Core is to facilitate the long-term conduct of rigorous, reproducible and innovative alcohol/HIV research. Over the next five years, the BDM Core will collaborate closely with International URBAN ARCH Center investigators by providing statistical expertise and effective data management to two research projects focused on understanding the role of alcohol use on TB acquisition, active disease, and lung disease after TB treatment among persons living with HIV (PLWH) in order to accelerate the future development of interventions that can reduce alcohol’s impact on TB-related morbidity and mortality among PLWH. The BDM Core will provide statistical and data management leadership in all phases of research to ensure high standards for data quality and statistical analyses. The BDM Core brings together an experienced team of investigators uniquely qualified to support the International URBAN ARCH Center based on their extensive knowledge of underlying scientific and clinical issues relevant to alcohol, HIV, and TB, and their long history of productive collaboration with URBAN ARCH investigators. Having this dedicated BDM Core will enhance the synergy and productivity of investigators, promote the validity and generalizability of the scientific findings, promote data sharing, and ultimately elevate the understanding of the impact of alcohol on the spectrum of TB infection among PLWH.