Wake Forest NCORP Research Base

维克森林NCORP癌症中心研究基地(WF NCORP RB)的总体目标是改善 通过制定、实施和成功完成癌症护理，提高患者福祉和癌症护理质量 创新和可行的癌症控制和癌症护理服务(CCDR)临床研究。差不多了 作为CCOP和现在的NCORP研究基地，维克森林公司二十年来一直专注于 癌症控制和CCDR研究，强调有效的操作流程和广泛的 与我们的NCORP社区站点和少数族裔服务不足的社区站点合作伙伴的互动。在.期间 NCORP网络的头4年，WF NCORP RB：开放了7项癌症控制和3项CCDR研究；登记 WF NCORP RB研究的1140名参与者；获得了5个额外概念和方案的批准，带来 4 420多名参与者的现行和待决审判的剩余和计划应计总额；实现了 33%的种族/少数民族参与者以及68%的妇女、14%的农村居民和26%的年龄 65岁或以上。在接下来的6年里，我们将通过以下方式加强和巩固这个非常成功的平台 完成以下具体目标：具体目标1：扩大我们的癌症控制临床研究活动 在以下领域：癌症治疗的心血管并发症；放射和化疗引起的 神经认知毒性；以及其他癌症和治疗相关症状和相关结果 由NCI指导委员会和那些通常与新出现的治疗相关的委员会优先考虑 范例。具体目标2：阐明和干预患者、家庭、临床医生和组织因素 影响癌症护理的提供，强调生存护理，非正式的癌症护理人员和 开展循证支持性护理服务。具体目标3：阐明生物机制 新的和创新的多学科中潜在的癌症和与治疗相关的症状和毒性 合作研究利用我们不断增长的血液、尿液和唾液样本生物库。 具体目标4：通过注重差异的研究确定和解决癌症差异的决定因素， 综合目标侧重于服务不足的人口，并有针对性地招募种族和族裔少数群体和 在所有维克森林NCORP研究调查中，服务不足的人口。具体目标5：培训 下一代癌症控制和CCDR研究人员通过早期职业生涯的指导和参与 WF NCORP活动中的教师、肿瘤学实习生、博士后研究员和学生。我们正在进行的和 拟议的癌症控制和CCDR研究将通过提供最佳实践来继续改善肿瘤学护理 用于症状和后遗症管理以及高效、以患者为中心、循证的癌症护理 为不同的患者群体提供服务。在下一个资助期，WF NCORP RB将帮助加快 通过与社区的密切合作，转化癌症控制和癌症护理服务方面的知识 以及为今后的传播和实施而设计的少数群体服务不足的网站和研究。

The overarching goal of the Wake Forest NCORP Cancer Center Research Base (WF NCORP RB) is to improve patient well-being and the quality of cancer care by developing, implementing and successfully completing innovative and feasible Cancer Control and Cancer Care Delivery (CCDR) clinical research studies. For nearly two decades as a CCOP and now NCORP Research Base, Wake Forest has maintained an exclusive focus on Cancer Control and CCDR studies and has emphasized efficient operational processes and extensive interactions with our NCORP Community Site and Minority Underserved Community Site partners. During the first 4 years of the NCORP network, the WF NCORP RB: opened 7 Cancer Control and 3 CCDR studies; enrolled 1,140 participants on WF NCORP RB studies; obtained approval for 5 additional concepts and protocols bringing the total remaining and planned accrual for active and pending trials to over 4,420 participants; and achieved a 33% accrual rate of racial/ethnic minority participants, as well as 68% women, 14% rural residents and 26% age 65 or greater. Over the next 6 years, we will build on and strengthen this highly successful platform by accomplishing the following Specific Aims: Specific Aim 1: Extend our cancer control clinical research activities in the following areas: cardiovascular complications of cancer therapy; radiation and chemotherapy-induced neurocognitive toxicities; and additional cancer and treatment-related symptoms and related-outcomes prioritized by NCI steering committees and those commonly associated with novel emerging treatment paradigms. Specific Aim 2: Elucidate and intervene upon patient, family, clinician, and organizational factors that influence cancer care delivery, emphasizing survivorship care, informal cancer caregivers and implementation of evidence-based supportive care services. Specific Aim 3: Illuminate biological mechanisms underlying cancer and treatment-related symptoms and toxicities in new and innovative multidisciplinary collaborative studies taking advantage of our growing biobank of blood, urine and salivary fluid specimens. Specific Aim 4: Identify and address determinants of cancer disparities via disparities-focused studies, integrated aims focused on underserved populations, and targeted recruitment of racial and ethnic minority and underserved populations across all Wake Forest NCORP research investigations. Specific Aim 5: Train the next generation of Cancer Control and CCDR researchers through mentoring and involvement of early career faculty, oncology trainees, post-doctoral fellows, and students in WF NCORP activities. Our ongoing and proposed Cancer Control and CCDR studies will continue to improve oncology care by informing best practices for symptom and late effect management as well as efficient, patient-centered, evidence-based cancer care delivery for diverse patient populations. In the next funding period, the WF NCORP RB will help accelerate the translation of knowledge in cancer control and cancer care delivery through close partnership with community and minority underserved sites and studies designed for future dissemination and implementation.