Diversity Supplement for Kristina Bell: Biopsychosocial pain predictors of mobility decline in aging

A.项目摘要或摘要：行动不便影响了大约30%的60-69岁的人，40% 70-79岁的人，以及55%的80岁或以上的人。新出现的横断面证据表明 自我报告的肌肉骨骼疼痛可能是年龄相关性活动能力下降的主要驱动因素之一。尽管 这一证据表明，仍然存在显著的知识差距，因为慢性肌肉骨骼之间的关系 疼痛、衰老、活动能力、心理社会功能和大脑还没有在同一年龄的人中被纵向研究过。 个人。我们的前瞻性研究设计将为疼痛相关脑变化的作用提供新的信息 随着与年龄相关的流动性的预测因素下降。拟议的工作将使我们能够确定疼痛是否 以及大脑结构和功能预测纵向活动能力下降(目标1)，以及大脑是否测量 前瞻性地调解疼痛-活动关联(目标2)。拟议的工作融合了多个研究领域 在生物心理社会方法中研究老年人的疼痛和行动能力。

A. Project Summary or Abstract: Mobility disability impacts approximately 30% of individuals aged 60-69, 40% of individuals aged 70-79, and 55% of individuals age 80 or older. Emerging cross-sectional evidence suggests that self-reported musculoskeletal pain may be one of the major drivers of age-related mobility decline. Despite this evidence, significant knowledge gaps remain because the relationships among chronic musculoskeletal pain, aging, mobility, psychosocial function, and the brain have not been studied longitudinally in the same older individuals. Our prospective study design will provide novel information on the role of pain-related brain changes as predictive factors of age-related mobility decline. The proposed work will allow us to determine whether pain as well as brain structure and function predict mobility decline longitudinally (Aim 1) and whether brain measures mediate the pain-mobility association prospectively (Aim 2). The proposed work integrates multiple fields of study within a biopsychosocial approach to study pain and mobility in the older population.