Biospecimen Core

摘要--生物质学家核心 生物素核心对于获取所有生物素、验证“正常健康组织”是必不可少的。 所有组织和相关生物液/非组织标本的诊断、处理和分配 气味。将多个久负盛名的杜克大学机构与高度专业化的协作 能力是这一核心的独特优势。我们是全国公认的生物资源库，也是世界上最高的 器官移植中心设在该国。生物库活动与护理标准并行进行 活组织检查、预定的外科手术、身体解剖和器官捐赠者的采购。这个核心的目标 是提供具有特殊质量控制措施的生物样品服务，使细胞的组织图谱成为可能 正常健康组织中的衰老生物标记物在整个生命周期(胎儿/围产期到老年人)。这一核心将 由一个在尸检、器官捐赠者和外科组织采购方面具有专业知识的团队领导。为了实现我们的目标 目标，我们将致力于1)有效地识别、获取和验证高质量的正常健康组织的诊断 和基于严格标准的同步生物液/非组织标本，2)处理高质量的正常健康 用于相关分析的组织和3)确保样品管理的质量保证和质量控制； 标本跟踪和生物库信息管理，实现所有SENet组织的最佳库组织共享 受资助的机构。我们的长期目标是不断发展，以满足我们调查人员的需求 通过法规修改、后勤修改、添加到服务菜单或创建解决方案 具有挑战性的研究问题。

ABSTRACT – Biospecimen Core The Biospecimen Core is essential for the acquisition of all biospecimens, verification of “normal healthy tissue” diagnosis, processing and allocation of all tissue and associated biofluids/non-tissue specimens required for SCENT. Integration of multiple, well-established Duke institutions with highly specialized collaborative capabilities is a unique strength of this Core. We are a nationally recognized biorepository and one of the highest organ transplantations centers in the country. Biobanking activities occur in parallel with standard of care biopsies, scheduled surgical procedures, autopsies and organ donor procurements. The objective of this Core is to provide biospecimen services with exceptional quality control measures to enable tissue mapping of cellular senescence biomarkers in normal healthy tissues across the lifespan (fetal/perinatal to elderly). This Core will be led by a team with expertise in autopsy, organ donor and surgical tissue procurement. To accomplish our goals, we will work to 1) efficiently identify, procure and verify diagnoses of high-quality normal healthy tissue and concurrent biofluids/non-tissue specimens based on stringent criteria, 2) process high-quality normal healthy tissues for correlative analyses and 3) ensure quality assurance and quality controls for sample management, specimen tracking and biobanking informatics management for optimal banked tissue sharing for all SenNet funded institutions. Our long-term goal is to constantly evolve to meet the needs of our investigators, either through regulatory modifications, logistical modifications, additions to the service menu, or in creating solutions to challenging research problems.