Administrative Core

RCA项目总结 我们P01的首要目标是在痴呆症患者中部署高价值的纵向人群数据 研究(开发AD研究)，是创建一个综合的研究计划，考虑到 痴呆症的更广泛的医疗、卫生系统和社会背景，对患者和家庭以及 这在以前的研究中没有得到充分的考虑。我们的重点是研究问题， 要求使用基于人口的数据资源，不能通过更机械的方式来解决 以及时或具有成本效益的方式进行重点研究。P01支持以下研究：a)检查复合体 痴呆症与其他严重疾病的相互作用；b)确定临床和社会破坏性事件的影响 关于疾病轨迹和结果；c)探索痴呆症背景下的药物处方；和d) 探讨基于社区的护理模式(临终关怀和居家医疗)如何满足 痴呆症患者及其家人在患病期间的健康状况。利用我们的过往记录进行 采用HRS和NHATS丰富、全面和纵向数据的开创性研究， 我们将创造必要的知识，以提高痴呆症患者及其照顾者的生活质量。 RCA将提供对P01的协调和监督，以及所需的愿景和领导 并将我们的研究成果转化为医疗保健的改善。RCA的具体目标是： ·SA 1：支持老年痴呆症患者的科学创新，确保定期、持续的 协调所有核心和项目之间的科学互动、规划、学习和反馈； 以最佳效率有效利用共享资源； ·SA2：提供日常管理，包括编写行政文件； 管理所有项目和核心的财务事项，包括监督所有预算、资源和 分包合同；管理数据使用协议、数据安全、人类主体审查； ·SA 3：监测研究进展，实施必要的补救措施，并确保及时出版和 传播研究成果； ·SA 4：利用我们在OAIC网络和国家姑息治疗研究中心中的国家作用 传播我们的发现、资源和编程代码，并提供“办公时间”和资源 全国各地的早期研究人员参与了痴呆症的基于人群的研究计划。 RCA促进了痴呆症的基于人群的研究，并通过一项 协调活动的全面框架。这一框架为研究提供了基础设施， 培养和促进协作，促进使用尖端方法，并传播 向科学界和政策界提供研究成果。RCA还结合了对职业生涯的创新关注 开发早期研究人员，并促进使用HRS和NHATS进行痴呆症研究。

RCA PROJECT SUMMARY The overarching goal of our P01, Deploying High Value Longitudinal Population-Based data in Dementia Research (DEVELOP AD RESEARCH), is to create an integrated program of research that considers the wider medical, health system, and social contexts of dementia that are important to patients and families and that have been inadequately considered in prior research. Our specific focus is on research questions that demand the use of population-based data resources and cannot be addressed by more mechanistically focused studies in a timely or cost-efficient manner. The P01 supports research that: a) examines the complex interaction of dementia and other serious illness; b) identifies the impact of clinical and social disruptive events on disease trajectory and outcomes; c) explores medication prescribing in the context of dementia; and d) examines how models of community-based care (hospice and home-based medical care) meet the needs of people with dementia and their families over the duration of illness. Leveraging our track record conducting groundbreaking research employing the rich, comprehensive, and longitudinal data of the HRS and NHATS, we will create the knowledge needed to enhance quality of life for persons with dementia and their caregivers. RCA will provide coordination and oversight of the P01 as well as the vision and leadership needed to advance and to translate our research findings into improvements in care. The specific aims of RCA are: · SA 1: To support scientific innovation for older adults with dementia by ensuring regular, ongoing coordinated scientific interaction, planning, learning and feedback between all cores and projects, and effective use of shared resources with optimal efficiency; · SA 2: To provide day-to-day management, including the preparation of administrative documents; management of fiscal matters of all projects and cores including oversight of all budgets, resources, and sub-contracts; and manage data use agreements, data security, human subjects review; · SA 3: To monitor research progress, implement necessary remediation, and ensure timely publication and dissemination of research findings; · SA 4: To leverage our national roles in the OAIC Network and National Palliative Care Research Center to disseminate our findings, resources, and programming codes and provide “office hours” and resources to early stage investigators across the nation engaged in population-based research programs in dementia. RCA advances population-based research in dementia and its translation into clinical practice through a comprehensive framework of coordinated activities. This framework provides infrastructure for research, nurtures and facilitates collaboration, promotes the use of cutting-edge methodologies, and disseminates results to the scientific and policy communities. RCA also incorporates an innovative focus on career development for early stage investigators and promotes the use of HRS and NHATS for dementia research.