Functional Genomics Core

项目摘要/摘要-功能基因组学核心(FGC) 功能基因组学核心(FGC)将提供所需的试剂、战略和技术专长 对遗传变异的有效研究可能在儿童风湿性和风湿性疾病中具有重要的机械意义 炎症性疾病。通过这样做，功能基因组核心将提高研究生产率和 通过有效地减少实施这些复杂的实验系统所需的“启动”时间， 从而降低了所需的成本和工作量，并允许进行更好的研究设计和更高质量的研究 调查人员将单独建立这项技术。此外，该核心将提供对最新状态的访问- 艺术技术，而不需要用户成为这些技术的专家。功能基因组学 CORE将是将基本进展转化为临床疾病应用的实用工具，其非常 对发病机制的重要见解。我们将专门提供咨询、协作、实践技术 专业知识和入门试剂到研究界进行功能基因组的执行和分析 实验(Aim1)和确定依赖于基因型的基因调控机制(Aim 2)以评估 自身免疫、自体炎症和免疫相关基因变异的生物学功能 风湿性儿科疾病。我们预计功能基因组学核心将成为研究的创新中心 社区，将科学家与工具和专业知识联系起来，将他们的研究项目带到下一个水平 加速发现导致遗传关联的分子机制 观察到的。

Project Summary/Abstract – Functional Genomics Core (FGC) The Functional Genomics Core (FGC) will provide reagents, strategic, and technical expertise required for efficient investigation of genetic variants likely to be mechanistically important in pediatric rheumatic and inflammatory diseases. In doing so, the Functional Genomics Core will enhance research productivity and efficiency by effectively reducing the “start-up” time required to implement these complex experimental systems, thus reducing costs and effort required and allowing for better study designs and higher quality studies than if investigators were to individually establish this technology. Further, this core will provide access to state-of-the- art technology without requiring the users to become experts in these technologies. The Functional Genomics Core will be a practical vehicle for the translation of basic advances to clinical disease applications and their very important insights into pathogenesis. We will specifically provide consultation, collaboration, hands-on technical expertise, and starter reagents to the research community to perform and analyze functional genomic experiments (Aim1) and identify genotype-dependent gene regulatory mechanisms (Aim 2) to assess the biological function of genetic variants associated with of autoimmune, autoinflammatory, and immune-related rheumatic pediatric diseases. We expect the Functional Genomics Core to be a hub of innovation for the research community, connecting scientists with the tools and expertise to take their research projects to the next level and to accelerate the discovery of the molecular mechanisms that are responsible for the genetic associations observed.