Cincinnati Rheumatic Diseases Resource Center

项目摘要/摘要--总体 辛辛那提风湿病资源中心(CRDRC)的中心目标是促进 促进对儿童风湿性疾病的认识，并为这些疾病提供新的治疗方法。这个 辛辛那提风湿病资源中心有两个明确的目标。目标1：提供以下资源 加强研究界的范围和广度，以推进理解的中心重点 炎症和生物学机制导致儿童风湿病的发生和发展 成年人。目标2：促进协作和跨学科方法，以促进实验室发现和 创造转化性研究机会，带来以患者为导向的重要成果。辛辛那提 风湿病资源中心包括一个管理核心和四个资源核心： ·儿科风湿病组织库(PRTR)负责人，Grant Schulert，医学博士 ·综合细胞表型核心(ICPC)。Leader，Sherry Thornton，博士 ·功能基因组学核心(FGC)。领导者，Leah Kottyan，博士 ·生物信息学和建模核心(BAM)。领导者，马修·维劳赫，博士 总而言之，这些资源形成了一个强大的基础设施，促进了精确度和预测性的发展 以基因组学和疾病机制为基础的医学方法。CRDRC将支持以疾病为基础的 跨发现连续体的研究，其中实验室发现产生翻译研究，从而导致 到临床试验。除了增进对儿童风湿病的了解外，CRDRC的目标是 包括征聘老牌调查员为该领域带来新专门知识、培养合作关系 在地方和国家研究界内，并鼓励致力于 致力于研究儿童风湿病。CRDRC的这些目标特别是 得到了试点研究方案的良好支持，该方案包括为P30核心内的工作提供资金，并扩展到 机构核心，以扩大影响并支持新的调查领域。CRDRC也将加强 通过当地研讨会、研讨会和座谈会的丰富计划，促进研究社区的发展。一位高度 富有成就和协作的研究人员社区已经到位，并期待着重大增长 通过新的招聘。创新的访问学者计划将有助于传播创新的 方法和充实来自历史上代表不足的群体的教职员工和受训人员 医学研究。这些特点共同为实现中心的目标创造了肥沃的土壤， 并最终加快研究，使儿童风湿病患者受益于他们的护理。

Project Summary / Abstract - Overall The central goal of the Cincinnati Rheumatic Disease Resource Center (CRDRC) is to promote studies that advance the understanding of pediatric rheumatic diseases and lead to new therapies for these diseases. The Cincinnati Rheumatic Disease Resource Center has two specific aims. Aim 1: Provide resources that will enhance the scope and breadth of the research community to advance the central focus of understanding inflammation and biological mechanisms contributing to the development of rheumatic disease in children and adults. Aim 2: Foster collaborations and interdisciplinary approaches to promote laboratory discoveries and generate translational research opportunities that lead to important patient-oriented outcomes. The Cincinnati Rheumatic Disease Resource Center includes an Administrative Core and four Resource Cores: · Pediatric Rheumatology Tissue Repository (PRTR) Leader, Grant Schulert, MD, PhD · Integrative Cell Phenotyping Core (ICPC). Leader, Sherry Thornton, PhD · Functional Genomics Core (FGC). Leader, Leah Kottyan, PhD · Bioinformatic and Modeling Core (BAM). Leader, Matthew Weirauch, PhD Collectively, these resources form a powerful infrastructure that fosters development of precision and predictive medical approaches based on genomics and disease mechanisms. The CRDRC will support disease-based research across the continuum of discovery, where laboratory findings generate translational studies that lead to clinical trials. In addition to advancing knowledge of pediatric rheumatic disease, the goals of the CRDRC include recruitment of established investigators to bring new expertise to the field, cultivation of collaborations within the local and national research community, and encouragement of young investigators committed to pursuing research careers focused on pediatric rheumatic disease. These goals of the CRDRC are particularly well supported by a Pilot Study Program that includes funding of work within the P30 cores and extends to institutional cores to broaden impact and support new areas of investigation. The CRDRC also will strengthen the research community through an enrichment program of local seminars, workshops, and symposia. A highly accomplished and collaborative community of researchers is already in place with expectations of major growth through new recruitment. An innovative Visiting Scholars program will aid in the dissemination of innovative approaches and the enrichment of faculty and trainees who are from groups historically underrepresented in medical research. Together, these attributes create fertile ground for accomplishing the goals of the CRDRC, and ultimately to accelerate research to benefit pediatric rheumatic disease patients in their care.