Cincinnati Rheumatic Diseases Resource Center

项目概要/摘要-总体 辛辛那提风湿病资源中心（CRDRC）的中心目标是促进以下研究： 促进对小儿风湿性疾病的理解，并为这些疾病提供新的治疗方法。的 辛辛那提风湿病资源中心有两个具体目标。目标1：提供资源， 扩大研究界的范围和广度，以促进理解的中心焦点 炎症和生物学机制有助于儿童风湿性疾病的发展， 成年人了目标2：促进合作和跨学科方法，以促进实验室发现， 产生转化研究的机会，导致重要的病人为导向的结果。辛辛那提号 风湿病资源中心包括一个行政核心和四个资源核心： ·儿科流变学组织库（PRTR）负责人，Grant Schulert，MD，PhD ·整合细胞表型核心（ICPC）。负责人，Sherry Thornton，博士 ·功能基因组学核心（FGC）。Leah Kottyan博士，负责人 生物信息学和建模核心（BAM）。组长，Matthew Weirauch博士 总的来说，这些资源形成了一个强大的基础设施，促进了精确和预测的发展。 基于基因组学和疾病机制的医学方法。CRDRC将支持基于疾病的 跨发现连续体的研究，实验室发现产生转化研究， 临床试验除了提高对小儿风湿性疾病的认识，CRDRC的目标 包括招聘资深调查员，为实地带来新的专业知识， 在地方和国家研究界，并鼓励年轻的研究人员致力于 从事儿科风湿病的研究工作。CRDRC的这些目标特别是 得到了试点研究计划的良好支持，该计划包括为P30核心内的工作提供资金，并扩展到 机构核心，以扩大影响和支持新的调查领域。CRDRC还将加强 通过当地研讨会、讲习班和专题讨论会的丰富计划，促进研究界的发展。一个高度 一个有成就和协作的研究人员社区已经到位，并期待着重大增长 通过新的招聘。创新的访问学者计划将有助于传播创新的 方法和充实教师和学员谁是从群体的历史上代表性不足， 医学研究总之，这些属性为实现CRDRC的目标创造了肥沃的土壤， 并最终加速研究，使儿科风湿病患者受益。

Project Summary / Abstract - Overall The central goal of the Cincinnati Rheumatic Disease Resource Center (CRDRC) is to promote studies that advance the understanding of pediatric rheumatic diseases and lead to new therapies for these diseases. The Cincinnati Rheumatic Disease Resource Center has two specific aims. Aim 1: Provide resources that will enhance the scope and breadth of the research community to advance the central focus of understanding inflammation and biological mechanisms contributing to the development of rheumatic disease in children and adults. Aim 2: Foster collaborations and interdisciplinary approaches to promote laboratory discoveries and generate translational research opportunities that lead to important patient-oriented outcomes. The Cincinnati Rheumatic Disease Resource Center includes an Administrative Core and four Resource Cores: · Pediatric Rheumatology Tissue Repository (PRTR) Leader, Grant Schulert, MD, PhD · Integrative Cell Phenotyping Core (ICPC). Leader, Sherry Thornton, PhD · Functional Genomics Core (FGC). Leader, Leah Kottyan, PhD · Bioinformatic and Modeling Core (BAM). Leader, Matthew Weirauch, PhD Collectively, these resources form a powerful infrastructure that fosters development of precision and predictive medical approaches based on genomics and disease mechanisms. The CRDRC will support disease-based research across the continuum of discovery, where laboratory findings generate translational studies that lead to clinical trials. In addition to advancing knowledge of pediatric rheumatic disease, the goals of the CRDRC include recruitment of established investigators to bring new expertise to the field, cultivation of collaborations within the local and national research community, and encouragement of young investigators committed to pursuing research careers focused on pediatric rheumatic disease. These goals of the CRDRC are particularly well supported by a Pilot Study Program that includes funding of work within the P30 cores and extends to institutional cores to broaden impact and support new areas of investigation. The CRDRC also will strengthen the research community through an enrichment program of local seminars, workshops, and symposia. A highly accomplished and collaborative community of researchers is already in place with expectations of major growth through new recruitment. An innovative Visiting Scholars program will aid in the dissemination of innovative approaches and the enrichment of faculty and trainees who are from groups historically underrepresented in medical research. Together, these attributes create fertile ground for accomplishing the goals of the CRDRC, and ultimately to accelerate research to benefit pediatric rheumatic disease patients in their care.