Administrative Core

开发和验证用于癌症早期检测的生物标志物需要一个团队 调查人员和资源从发现到验证阶段再到最终阶段 目标是临床批准和有用的测试。该Biomarker表征中心建议 开发和验证基于血液的癌症特异性DNA甲基化生物标记物 来自NCI指定的三个综合癌症中心(The 匹兹堡大学希尔曼综合癌症中心，西德尼·基梅尔 约翰霍普金斯大学综合癌症中心和马里兰大学马琳分校 斯图尔特·格林鲍姆综合癌症中心)来完成这项复杂的任务。至 协调和支持这些努力，一个行政核心将整合EDRN BCC的活动 调查人员。这个生物标记表征中心的行政核心负责监督， 协调和支持这一多学科项目的活动。通过监督和 为支持这些活动，生物标志物开发实验室的各个组成部分 和Biomarker参考实验室能够有效地实现其目标和 将其活动与BCC的其他组成部分(BDL和BRL)、与其他NCI整合 方案和其他EDRN中心(BCC、CVCS和DMCC)。

The development and validation of biomarkers for the early detection of cancer requires a team of investigators and resources to move from discovery through stages of validation to the ultimate goal of a clinically approved and useful test. This Biomarker Characterization Center proposes to develop and validate blood-based cancer specific DNA methylation biomarkers by bringing together investigative teams from three NCI designated Comprehensive Cancer Centers (The UMPC Hillman Comprehensive Cancer Center at the University of Pittsburgh, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, and The University of Maryland Marlene & Stewart Greenebaum Comprehensive Cancer Center) to accomplish this complex task. To coordinate and support these efforts, an administrative core will integrate activities of EDRN BCC investigators. The administrative core of this Biomarker Characterization Center oversees, coordinates and supports the activities of this multidisciplinary program. Through overseeing and supporting these activities, the individual components of the Biomarker Development Laboratory and the Biomarker Reference Laboratory are able to effectively accomplish their objectives and integrate their activities with other components of the BCC (BDL and BRL), with other NCI programs and with other EDRN centers (BCCs, CVCs and the DMCC).