Support Mentoring of Early Career Clinical Researchers from Diverse Backgrounds

此应用程序响应RFA-DK-22012，调查员奖，以支持早期职业指导 来自不同背景的研究人员为加拉格尔博士提供受保护的努力和资源 建立由NIDDK资助的研究人员和导师，为研究生和 来自不同背景和代表性不足的群体的博士后研究员。加拉格尔博士有广泛的 有指导研究员和初级教员的经验，包括来自代表性不足的群体。她的领导角色 作为减重状态生理学(POWERS)研究中的MPI(5UH3DK128302-03：MPIS Gallagher， Mayer，Leibel，Rosenbaum)提供了丰富的训练环境，接受了一系列不同的措施 和方法论。众所周知，肥胖是导致人类疾病和医疗费用的主要因素。 适度的体重减轻可以减轻这些表型中的许多严重程度--或者完全逆转。维护 体重减少7%的人、苗条的人和肥胖的人会引起能量消耗的动态平衡变化 (减少)和饥饿(增加)，这往往会恢复体重。我们假设地球的异质性 反应，目前还没有特征，解释了减轻体重的长期成功的差异 维修。POWER将前瞻性地审问有助于 减肥后体重变化的变异性。患有肥胖症的健康成年人将在之前和 在减肥后立即(阶段1)，并在随访12个月期间观察阶段2。参与者 在18个月的研究中，将在4个时间点进行广泛的表型分析：体重，身体成分，总 能量消耗、能量摄入、静息能量消耗、体力活动、运动效率、睡眠 质量、食物选择、行为和心理社会评估。力量(在纽约营养肥胖症 哥伦比亚大学研究中心)将作为拟议的K24指导和 培训计划将整合在一起。指导目标1-研究：在POWERS研究的框架内， 为受训者提供临床研究方面的接触和培训，这些研究涉及先进的 艺术方法、研究中的严谨性和重复性培训、人类受试者遵从性和科学性 手稿和赠款写作；指导目标2-职业发展：参加并在以下地点发表研究报告 地方和全国会议(例如，肥胖协会主办的肥胖周刊)；出席 接触到目前关于肥胖的方法学、生物学、心理学和营养学方面的研究， 与相关领域的专家建立联系，职业发展，指导如何有效地与 来自不同背景和学科的研究人员。作为一名导师，我的主要培训目标是发展技能 成为一个更具文化意识的导师，以最佳方式指导来自不同背景的早期职业调查人员。 具有增强的研究和领导技能，手稿和赠款撰写经验，以及 在导师网络的帮助下，学员将处于成长和事业成功的有利地位。

This application responds to RFA-DK-22012, Investigator Award to Support Mentoring of Early Career Researchers from Diverse Backgrounds to provide protected effort and resources to Dr. Gallagher, an established NIDDK-funded investigator and mentor to provide high quality mentoring to graduate students and postdoctoral fellows from diverse backgrounds and underrepresented groups. Dr. Gallagher has extensive experience mentoring fellows and junior faculty, including from underrepresented groups. Her leadership role as MPI in The Physiology of The Weight Reduced State (POWERS) study (5UH3DK128302-03: MPIs Gallagher, Mayer, Leibel, Rosenbaum) provides a rich environment for training with exposure to a diverse array of measures and methodologies. It is well known that obesity is a major contributor to human illness and health care costs. Modest weight loss can mitigate the severity – or entirely reverse - many of these phenotypes. Maintenance of a 7% reduced body in persons, lean and with obesity invokes homeostatic changes in energy expenditure (decreased) and hunger (increased) that tend to restore body weight. We hypothesize that the heterogeneity of response, currently not characterized, accounts for differences in long-term success for reduced weight loss maintenance. POWERS will prospectively interrogate the physiological/behavioral systems that contribute to variability in weight change following weight loss. Healthy adults with obesity will be studied before and immediately after weight loss (Phase 1), and during the follow-up 12 months observational Phase 2. Participants will be extensively phenotyped at 4 timepoints across the 18 months study: weight, body composition, total energy expenditure, energy intake, resting energy expenditure, physical activity, exercise efficiency, sleep quality, food choice, behavioral and psychosocial assessments. POWERS (within the New York Nutrition Obesity Research Center at Columbia) will serve as the framework through which the proposed K24 mentoring and training program will be integrated. Mentoring Aim 1-Research: within the framework of POWERS study, to provide the trainee with exposures and training in the conduct of clinical research involving advanced state-of- the art methods, training in rigor and reproducibility in research, human subject compliance, and scientific manuscript and grant writing; Mentoring Aim 2-Career Development: attend and give research presentations at local and national meeting (eg, ObesityWeek sponsored by The Obesity Society); attendance of seminars for exposure to current research on methodological, biological, psychological, and nutritional aspects of obesity, networking with experts in the related fields, career development, guidance on how to effectively collaborate with researchers from diverse backgrounds and disciplines. My primary training aim as a mentor is to develop skills to be a more culturally aware mentor to optimally mentor early career investigators from diverse backgrounds. With enhanced research and leadership skills, manuscript and grant writing experience, and an established mentoring network, trainees will be well positioned to grow and be successful in their careers..