Next generation relaxin molecular probes and therapeutics

肽激素松弛素有望成为40多年来第一个治疗急性心力衰竭的新方法。然而，与其他治疗性肽一样，由于其被身体快速清除，因此其作用持续时间非常短。我的工作将利用强大的药物化学方法，开发新的松弛素类似物，通过与糖复合或制造松弛素聚合物，使其具有更长的作用。我还将生产更小的松弛素类似物，制造成本更低。

The peptide hormone relaxin is poised to be the first new treatment for acute heart failure in more than 40 years. However, like other therapeutic peptides, it has a very short duration of action due to its rapid clearance by the body. My work will utilize powerful medicinal chemistry methods to develop new analogues of relaxin that have much longer action by complexing it with sugar or making relaxin polymers. I will also produce smaller relaxin analogues that will be cheaper to manufacture.