Integrative Center for Precision Nutrition and Human Health

项目总结 这份提案回应了对美国国立卫生研究院现有拨款的行政补充的呼吁 精准营养与人类健康综合中心(Cobre- 营养)在夏威夷大学ʻI在MāNoA计划购买全反射X射线荧光(TXRF) 由Bruker AXS LLC制造的S4T-Star 200型光谱仪。TXRF光谱仪是一种最新的- ART台式设备，可快速分析各种样品中的超痕量元素含量，包括生物样品 液体、食物/补充剂、细胞、组织、细胞培养液、水和其他环境样品 样品的量和检测下限在ppb范围内。本行政机关的具体目标 补充请求是：1)向UH社区购买TXRF系统，由Core管理 科布雷-营养基础设施内的设施；以及2)提供访问、培训和技术支持 来自广泛的UH社区的研究人员使用TXRF系统。TXRF将设在 Cobre-Nutrition的工艺结构下的脂肪组学核心设施。建议的用户包括Research Cobre-Nutrition项目和试点项目负责人，以及来自以下院校的多个资助的PI UH系统。Cobre-Nutrition通过扩大几个科学项目的广度直接受益 结果。

PROJECT SUMMARY This proposal submission responds to a call for an Administrative Supplement to Existing NIH Grants for Equipment Purchase in which the Integrative Center for Precision Nutrition and Human Health (COBRE- Nutrition) at the University of Hawaiʻi at Mānoa aims to purchase a total reflection X-Ray fluorescence (TXRF) Spectrometer model S4 T-Star 200 manufactured by Bruker AXS LLC. The TXRF spectrometer is a state-of-the- art benchtop equipment to rapidly analyze ultra-trace element content in various samples, including biological fluids, food/supplements, cells, tissues, cell culture media, water, and other environmental samples, using small amounts of sample and with a detection limit at the ppb range. The specific aims of this Administrative Supplement request are: 1) to purchase a TXRF system to the UH community to be administered by a Core Facility inside the COBRE-Nutrition infrastructure; and 2) to provide access, training and technical support to researchers from the broad UH community in the use of the TXRF system. The TXRF will be housed in the Lipidomics Core Facility under the CRAFT structure of the COBRE-Nutrition. Proposed users include Research Project and Pilot Project Leaders of the COBRE-Nutrition, and multiple funded PIs from colleges and schools of the UH system. The COBRE-Nutrition benefits directly through expanding the breadth of several scientific project outcomes.