Mechanism of leukaemia suppression by the transcription factor Ikaros

急性淋巴细胞白血病的一个子集的特征是Ikaros基因突变。这些白血病对化疗反应差，需要新的治疗方法。我们发现了Ikaros在调节白血病细胞死亡中的新功能。该项目研究Ikaros如何调节细胞死亡，以及这是否是一种一般机制。了解Ikaros功能是改善这种侵袭性白血病治疗方法的一步。

A subset of acute lymphoblastic leukaemias are characterised by mutations in the Ikaros gene. These leukaemias respond poorly to chemotherapy and require novel therapeutic approaches. We have discovered a new function of Ikaros in regulating leukaemia cell death. This project investigates how Ikaros regulates cell death and whether this is a general mechanism. Understanding Ikaros function is a step toward improved treatments for this aggressive type of leukaemia.