Development of a highly sensitive and specific POCT testing asthma triggering allergic IgE

行政补充摘要 母项目的总体目标是开发并最终商业化一种新颖的即时检测 能够快速且高精度地检测对环境过敏原的过敏性IgE， 促进健康生活，减少少数群体健康差距。本行政补充申请是 旨在通过支持候选人来增强研究和创业劳动力的多样性， 克里斯蒂安·拉皮坦，建立标准化的程序，确保产品质量的一致性 侧流免疫分析（R-LFIA）快速检测装置。本行政副刊的研究项目 候选人的目的是表达、纯化、表征和使用来源于 细菌（E.大肠杆菌）以代替粗变应原提取物作为制备变应原-金的变应原源 纳米颗粒偶联物，以实现一致和准确的测试结果与R-LFIA。加强研究 候选人的创业能力是这种多样性补充的另一个主要目的。做 因此，申请公司Allerdia已经制定了一个指导计划;一个指导者与候选人互动的计划; 以及一项商业和创业增强计划。

Summary of Administrative Supplement The overall goal of the parent project is to develop and eventually commercialize a novel point-of-care test capable of rapidly and highly accurately detecting allergic IgE to environmental allergens as an approach to promote healthy living and reduce minority health disparities. This administrative supplement application is intended to enhance the diversity of the research and entrepreneurial workforce by supporting a candidate, Christian Lapitan, to establish a standardized procedure to ensure the consistent product quality of the reverse lateral flow immunoassay (R-LFIA) rapid test device. The research project of this administrative supplement for the candidate is to express, purify, characterize, and employ the recombinant allergens derived from bacteria (E. coli) to replace the crude allergen extracts as an allergen source for preparation of allergen-gold nanoparticle conjugates to achieve consistent and accurate test results with R-LFIA. Enhancement of research and entrepreneurial capability for the candidate is another major purpose of this diversity supplement. To do so, the applicant company Allerdia has developed a mentoring plan; a plan for mentor-candidate interactions; and a plan for business and entrepreneurship enhancement.