Developing and pilot testing a multidimensional intervention to improve HIV care outcomes among recently incarcerated people living with HIV in the Washington DC metropolitan area

总体研究计划 项目总结 哥伦比亚特区艾滋病研究中心(DC CFAR)的续签申请提供了 到目前为止，华盛顿特区CFAR的科学和公共卫生成就，描述了我们独特的全市范围、多个 体制模式，强调了CFAR所依赖的强有力的领导和行政基础设施 是建立的，并阐明了我们未来科学方向的愿景。 华盛顿特区的CFAR包括来自八个华盛顿合作机构的227名艾滋病毒调查人员-乔治·华盛顿， 乔治敦、霍华德和美国大学、退伍军人事务医学中心、国家儿童基金会 卫生系统，华盛顿卫生部和惠特曼-沃克健康。我们的使命是加强我们的多 促进和支持有助于结束华盛顿艾滋病毒流行的研究的机构努力， 华盛顿和更远的地方与政府和社区合作。与上一届相比取得的显著成就 资助期为我们的未来奠定了坚实的基础，包括我们资助的研究增加了46% BASE(FRB)从2015年的1,160万美元增加到2018年的1,700万美元；自2010年以来授予的试点奖励超过280万美元；761% 2010-2016年完成的试点奖励的投资回报；以及提供的1,100项核心服务 以及2015-2019年DC CFAR调查人员发表的667篇与艾滋病毒相关的文章。 在五年内提供280万美元的大量机构支持，以及众多科学和方案 创新正在进行中，DC CFAR处于有利地位，可以应对我们当地的关键挑战 流行病。DC CFAR的具体目标是： 目标1：提供科学领导和机构基础设施，以推动 八个合作的DC CFAR机构； 目标2：刺激和支持在基础、临床和医疗领域的创新和相应的艾滋病毒研究 预防以及社会和行为科学，同时促进跨学科方法 处理国家卫生研究院高度优先的艾滋病毒科学重点领域； 目标3：推动早期、新的和任职人数不足的妇女的发展和征聘 少数族裔艾滋病毒调查员；以及 目标4：加强DC CFAR之间的沟通和促进有意义的新合作 研究人员以及学术、政府、社区和临床合作伙伴。 为了实现这些目标，DC CFAR支持五个核心：提供科学领导的行政管理和 财政监督；发展计划，监督试点奖项和指导计划；以及基础科学， 临床和人口科学，以及社会和行为科学提供服务，以支持 创新和多学科的艾滋病毒研究。最后，DC CFAR支持两个科学工作组-- 艾滋病毒治疗和结束艾滋病毒流行--以促进在这些高度优先领域的研究。

OVERALL RESEARCH PLAN PROJECT SUMMARY This renewal application for the District of Columbia Center for AIDS Research (DC CFAR) presents the scientific and public health achievements of the DC CFAR to date, describes our unique citywide, multi- institutional model, underscores the strong leadership and administrative infrastructure upon which the CFAR is built and articulates a vision for our future scientific directions. The DC CFAR includes 227 HIV investigators from eight DC collaborating institutions – George Washington, Georgetown, Howard and American Universities, the Veterans Affairs Medical Center, Children's National Health System, DC Department of Health and Whitman-Walker Health. Our mission is to intensify our multi- institutional effort to promote and support research that contributes to ending the HIV epidemic in Washington, DC and beyond in partnership with government and community. Notable achievements from the previous funding period provide a strong foundation for our future, including a 46% increase in our Funded Research Base (FRB) from $11.6M in 2015 to $17.0M in 2018; over $2.8M in pilot awards granted since 2010; a 761% return on investment on completed pilot awards funded from 2010-2016; and >1,100 Core services provided and 667 HIV-related articles published by DC CFAR investigators from 2015-2019. With substantial institutional support of $2.8M over five years, and numerous scientific and programmatic innovations underway, the DC CFAR is well-positioned to respond to the critical challenges of our local epidemic. The Specific Aims of the DC CFAR are to: Aim 1: Provide scientific leadership and institutional infrastructure to advance HIV research among the eight collaborating DC CFAR institutions; Aim 2: Stimulate and support innovative and consequential HIV research in the basic, clinical, prevention and social and behavioral sciences while promoting an interdisciplinary approach to addressing the NIH high priority scientific HIV focus areas; Aim 3: Drive the development and recruitment of early stage, new, and women and underrepresented minority HIV investigators; and Aim 4: Enhance communication and foster meaningful new collaborations between DC CFAR investigators and academic, government, community and clinical partners. To achieve these aims, the DC CFAR supports five Cores: Administrative to provide scientific leadership and fiscal oversight; Developmental to oversee the pilot awards and mentoring programs; and Basic Sciences, Clinical and Population Sciences, and Social and Behavioral Sciences to provide services to support innovative and multi-disciplinary HIV research. Lastly, the DC CFAR supports two Scientific Working Groups – HIV Cure and the Ending the HIV Epidemic – to galvanize research in these high priority areas.