COVID-19 Administrative Supplement to K01: Adapting, Pilot Testing a Behavioral Intervention to Incorporate Advances in HIV Prevention for Black Young MSM in Alabama

项目摘要 此申请是对目前NIMH支持的K 01职业发展奖的行政补充 受到COVID-19疫情严重影响的地区。我的5年K 01从2019年5月开始，不到一年 在颁奖仪式上，COVID-19被宣布为全球紧急状态;所有人类受试者的研究和旅行都被停止。 大流行的大约三年发生在我K 01职业发展的黄金时期 影响培训目标和具体目标完成的奖励。 最初的5年指导研究科学家发展K 01奖的总体目标是支持海娜 Budhwani博士，公共卫生硕士成为艾滋病毒预防领域的独立调查员。拟建项目 旨在解决亚拉巴马的艾滋病毒危机，在那里，发生性行为的黑人年轻男子中未确诊的艾滋病毒感染率 男性（YMSM，18-29岁）超过20%。提出了四个与三个目标步调一致的培训目标 明确的目标。目标1包括社会理论方面的强化培训和指导计划。目标2包括 深入培训定性研究方法，包括如何进行焦点小组，深入访谈， 定性数据分析。目标1将在目标2之后进行，目的1是阐明经验， 信念，以及与黑人YMSM提供和利用艾滋病毒检测和预防服务相关的预测因素 使用定性研究方法，即深入访谈艾滋病毒外展工作人员，重点小组与黑人 YMSM，并对关键子团体成员进行深入采访，为《拯救兄弟》的改编提供信息 兄弟会（BSB）干预。目标3包括关于如何科学地适应 使用经验证的框架进行艾滋病毒行为干预，如干预绘图。目标2是适应 BSB干预措施包括快速检测和PrEP，以解决结构性障碍，并为黑人所接受 亚拉巴马的YMSM。目标4包括执行领域的全面培训和辅导 科学目标3，包括拟议的研究和K 01项目，是进行混合型1 适应性干预措施的有效性-实施试点研究。这个严格的项目包括密集的 在候选人的家乡大学和其他著名机构提供非常具体的培训 在UAB没有发现;来自高级HIV研究人员的全面指导;以及深思熟虑的研究策略 解决重大威胁、艾滋病毒未确诊率高以及艾滋病毒参与不足等问题 预防服务，包括PrEP，在黑色YMSM在亚拉巴马。建议的辅导 研究结果的培训将最终使候选人获得独立和发展 全面实施科学知情的R 01提案，以测试新的适应性干预措施。

PROJECT SUMMARY This application is for an administrative supplement to a current NIMH-supported K01 career development award that was severely affected by the COVID-19 pandemic. My 5-year K01 began in May 2019, and less than a year into the award, COVID-19 was declared a global emergency; all human subjects research and travel was halted. The approximately three years of the pandemic occurred in the prime years of my K01 career development award affecting both training objective and specific aim completion. The overall goal of the original 5-year Mentored Research Scientist Development K01-Award is to support Henna Budhwani, PhD, MPH become an independent investigator in the field of HIV prevention. The proposed project seeks to address the HIV crisis in Alabama, where rates of undiagnosed HIV in Black young men who have sex with men (YMSM, 18-29 years) exceed 20%. Four training objectives are proposed that are in lockstep with three specific aims. Objective 1 includes an intensive training and mentoring plan in social theory. Objective 2 includes in-depth training on qualitative research methods including how to conduct focus groups, in-depth interviews, and qualitative data analysis. Aim 1, which will be conducted after Objective 2, is to elucidate experiences, beliefs, and predictors related to delivery and utilization of HIV testing and prevention services by Black YMSM using qualitative research methods, namely in-depth interviews with HIV outreach staff, focus groups with Black YMSM, and in-depth interviews with members of key sub-groups to inform the adaptation of the Brothers Saving Brothers (BSB) intervention. Objective 3 includes didactic and hands-on training on how to scientifically adapt HIV behavioral interventions using validated frameworks, such as intervention mapping. Aim 2 is to adapt the BSB intervention to include rapid testing and PrEP, to address structural barriers, and to be acceptable to black YMSM in Alabama. Objective 4 includes comprehensive training and mentoring in the field of implementation science. Aim 3, which concludes the proposed research study and K01 project, is to conduct a hybrid type 1 effectiveness-implementation pilot study of the adapted intervention. This rigorous project includes intensive training at the candidate's home university and from other prominent institutions that offer very specific training not found at UAB; comprehensive mentoring from senior HIV researchers; and a thoughtful research strategy that addresses significant threats, high rates of undiagnosed HIV and insufficient engagement with HIV prevention services, including PrEP, in Black YMSM in Alabama. The combination of the proposed mentoring and training with study findings will culminate in the candidate's attainment of independence and development of a full-scale implementation science-informed R01 proposal to test the new adapted intervention.