Adjuvant Comparison and Characterization (HIV)

佐剂比较和表征（ACC）计划的目标是支持佐剂与临床相关疫苗/抗原平台的并行比较，并建立通过不同机制起作用的佐剂的全身和组织特异性免疫学特征（“免疫指纹”）。HIV疫苗开发的一个主要挑战是学习如何诱导强大和持久的抗体反应，以防止粘膜感染。克服这一挑战的关键一步是开发适当刺激强大和持久免疫反应的佐剂。本项目的目标是评估3种不同佐剂对增强HIV Env中和抗体应答的幅度和持久性的影响。

The goal of the Adjuvant Comparison and Characterization (ACC) program is to support side-by-side comparison of adjuvants in combination with clinically relevant vaccine/antigen platforms, and to establish both systemic and tissue-specific immunological profiles (“immune fingerprints”) of adjuvants that work through different mechanisms. A major challenge for HIV vaccine development is learning how to induce robust and durable antibody responses that protect against mucosal infection. A critical step on the path to overcoming this challenge are developing adjuvants that appropriately stimulate robust and durable immune responses. The goal of this project is to assess the impact of 3 different adjuvants on enhancing the magnitude and durability of neutralizing antibody responses against HIV Env.