Reducing blood pressure in mid-life adult binge drinkers: the role of microvascular function and sympathetic activity

项目总结/摘要 这种补充支持多样性的候选人，在运动机能学二年级的博士生，并培养 他的研究生涯发展成为血管生理学和酒精领域的科学家， 相关健康研究。根据这一补充规定，开展研究培训和专业发展活动， 通过战略指导计划促进，并将其纳入父R 00项目。父母R 00补助金 一直以微血管功能和交感神经活动为目标， 潜在的酒精归因于收缩压升高的贡献和防止负面的健康 中年人的后果。然而，酗酒，最常见的过量饮酒模式， 使用，也可以通过增加动脉硬度引起收缩压升高，理论上， 导致血流动力学改变，如主动脉波反射增强和颈动脉波强度增强。 这些血流动力学变化不仅在血压调节中起重要作用， 心脏和大脑的功能。了解酒精引起的动脉硬化和相关的 血流动力学变化是重要的，因为它有助于预测器官损伤的后续进展， 酒精多样性候选人将完成拟议的研究，以解决总体假设- “长期酗酒导致中年人主动脉和颈动脉血流动力学的变化， 动脉硬化”在补充期间，多元化候选人将接受 主项目的PI，以提高他在酒精使用评估和有害影响方面的知识和技能 对动脉硬化和血液动力学的影响他还将接受专业指导 发展，以提高他的沟通，领导和管理技能，以及专业精神。 PI是一名女性早期研究者，致力于其职业和专业发展 实习生根据本补充建议的培训计划将由一名高级教员，博士促进。 R.马修兄弟这种补充不仅有助于促进候选人的进展，他的下一个 职业生涯的阶段，但也有助于丰富PI的接触计划与学员的参与，从不同的 在她的职业生涯的早期阶段，她的背景和建立她的实验室。此外，增加 来自非传统背景的科学家（即，运动学）在酒精研究领域将提高 酒精研究的多样性，最终加快了酒精相关健康研究的步伐。因此，我们认为， 这种多样性补充与NIAAA的首要使命和研究优先领域是一致的。

Project Summary/Abstract This supplement supports the diversity candidate, a second-year doctoral student in Kinesiology, and fosters his research career development toward becoming a scientist in the field of vascular physiology and alcohol- related health research. The research training and professional development activities, under this supplement, are facilitated by a strategic mentoring plan and incorporated into the parent R00 project. The parent R00 grant has been targeting microvascular function and sympathetic nerve activity to understand the mechanisms underlying alcohol-attributable contribution to elevated systolic blood pressure and prevent the negative health consequences in mid-life adults. Nevertheless, binge drinking, the most common pattern of excessive alcohol use, can also cause elevated systolic blood pressure through increased arterial stiffness which, in theory, results in hemodynamic changes, such as enhance aortic wave reflection and carotid artery wave intensity. These hemodynamic changes play a significant role not only in blood pressure regulation but also in the function of the heart and the brain. Understanding alcohol-induced arterial stiffening and the related hemodynamic changes is significant because it helps predict the subsequent progression of organ injury by alcohol. The diversity candidate will complete the proposed research to address the overarching hypothesis – “chronic binge drinking contributes to the changes in aortic and carotid hemodynamic in mid-life adults due to arterial stiffness.” During the supplement period, the diversity candidate will receive mentored training with the PI of the parent project to enhance his knowledge and skills in alcohol use assessments and the harmful effect of binge drinking on arterial stiffness and hemodynamics. He will also receive mentored professional development to enhance his communication, leadership, and management skills, as well as professionalism. The PI is a female early-stage investigator and is committed to career and professional development for her trainees. The proposed training plan under this supplement will be facilitated by a senior faculty member, Dr. R. Matthew Brothers. This supplement will not only help facilitate the candidate’s progress toward his next stage of career, but also help enrich the PI’s reach program with the involvement of trainees from diverse backgrounds and establish her laboratory at the early stage of her career. In addition, increasing the number of scientists from non-traditional backgrounds (i.e., kinesiology) in the field of alcohol research will enhance the diversity of alcohol research, ultimately accelerating the pace of research in alcohol-related health. Therefore, this diversity supplement is consistent with the overarching mission and research priority areas of NIAAA.