Regulators of retinal metabolism in healthy and degenerating retinas

摘要： 视网膜具有高代谢活性，视网膜变性与线粒体损伤有关。 功能障碍、代谢失调和毒性氧化损伤。然而，人们对如何做到这一点知之甚少。 代谢在正常条件下维持或在退化的视网膜中失调。AMPK（AMP- 活化的蛋白激酶）是高度代谢组织中代谢的关键调节剂， 调节光感受器的代谢，其在视网膜代谢中的作用将在本研究中进行严格研究。 使用功能获得和功能丧失方法的拟议项目。过氧化物酶体增殖激活 受体γ辅激活因子-α（PGC-1α）和β（PGC-1β）是线粒体生物发生的关键调节因子。 腺苷一磷酸依赖性激酶（AMPK）是PGC-1活性的重要调节因子。我们的目标 本研究旨在探讨AMPK和PGC-1活性在视网膜光感受器中的作用。

Abstract: The retina has high metabolic activity, and retinal degenerations have been associated with mitochondrial dysfunction, dysregulation of metabolism, and toxic oxidative damage. However, little is known about how metabolism is maintained under normal conditions or is dysregulated in degenerating retinas. AMPK (AMP- activated protein kinase) is a key regulator of metabolism in highly metabolic tissues and is a candidate to regulate metabolism in photoreceptors, and its role in retinal metabolism will be rigorously studied in this proposed project using both gain-of-function and loss-of-function approaches. Peroxisome proliferator-activated receptor gamma coactivator-alpha (PGC-1α) and beta (PGC-1β) are key regulators of mitochondrial biogenesis. Adenosine monophosphate dependent kinase (AMPK) is an important regulator of PGC-1 activity. Our goal in this study is to determine the roles of AMPK and PGC-1 activity in retinal photoreceptors.