UW Comprehensive Cancer Center Support

项目总结/摘要 威斯康星州大学Carbone癌症中心（UWCCC）寻求49 - 53年的持续资助， 进一步加快其使命，以大幅减少其流域内外的癌症负担- 威斯康星州。UWCCC是威斯康星州大学医学院内的矩阵中心 和公共卫生（SMPH），是由来自38个部门和9所学校的218名教师组成的 威斯康星大学麦迪逊分校（UW）。我们的成员通过6个项目进行癌症护理、研究和教育。 科学计划（人类癌症病毒学，癌症遗传和表观遗传机制，肿瘤 微环境，成像和辐射科学，发育治疗学，癌症预防和 控制）由12个共享资源支持。在目前的赠款期间（2017 - 2021年），领导层已 成功招募了超过40名新成员和更多样化的成员，并加强了现有或新的基础设施 促进我们的会员出版了3，351篇与癌症相关的手稿（31%是跨项目或项目内的， 53%机构间），高影响因子期刊（≥ 10）的比例显著增加（先前的赠款， 11%，而目前为23%），增加了我们的NCI研究（直接2017年1860万美元，2021年2490万美元）和总额 研究资金（直接2017 $70.4米，2021 $76.3米），获得更多的多项目奖（P，U），支持 更多的学员和支持社区在我们扩大的覆盖范围。 UWCCC将通过培养一个多样化和支持性的癌症社区，可靠的， 基础设施和高效资源。UWCCC致力于减少我们流域的癌症负担 通过优先研究领域（例如，创新疗法和生物标志物，癌症成像， 扩大的基于人群的癌症研究），增强的研究平台（例如，改进临床研究 基础设施和共享资源），加强努力建立与特派团有关的慈善事业，并扩大当地- 全球伙伴关系。

PROJECT SUMMARY/ABSTRACT The University of Wisconsin Carbone Cancer Center (UWCCC) seeks continued funding for years 49-53 to further accelerate its mission to dramatically reduce the burden of cancer within and beyond its catchment – the State of Wisconsin. The UWCCC, which is a matrix center within the University of Wisconsin School of Medicine and Public Health (SMPH), is composed of 218 faculty members from 38 departments and 9 schools of the University of Wisconsin-Madison (UW). Our members pursue cancer care, research, and education through 6 scientific programs (Human Cancer Virology, Cancer Genetic and Epigenetic Mechanisms, Tumor Microenvironment, Imaging and Radiation Sciences, Developmental Therapeutics, and Cancer Prevention and Control) supported by 12 Shared Resources. During the current grant period (2017-2021), leadership has successfully recruited >40 new and more diverse members and strengthened existing or new infrastructure facilitating our membership publishing 3,351 cancer-relevant manuscripts (31% inter- or intra-programmatic, 53% inter-institutional) with a significant increased proportion in high (≥10) impact factor journals (prior grant, 11% compared to current 23%), increasing our NCI research (Direct 2017 $18.6M, 2021 $24.9M) and total research funding (Direct 2017 $70.4M, 2021 $76.3M), obtaining more multi-project awards (P, U), supporting more trainees and supporting communities throughout our expanded catchment. The UWCCC will accomplish this mission through nurturing a diverse and supportive cancer community, reliable infrastructure, and efficient resources. The UWCCC worked to decrease the burden of cancer in our catchment and beyond through prioritized research areas (e.g., innovative therapies and biomarkers, cancer imaging, and expanded population-based cancer research), enhanced research platforms (e.g., improved clinical research infrastructure and shared resources), increased efforts to build mission-related philanthropy, and expanded local- to-global partnerships.