Idaho INBRE Program

项目总结 爱达荷州INBRE-4计划的目标是继续增强和加强爱达荷州的执行能力 并支持生物医学研究。这一团队科学副刊，动态细胞事件在组装 脊椎动物之眼，将通过聚集爱达荷大学(UI)的三名研究人员来推进这一目标 在发育神经生物学、免疫学/神经胶质生物学/成像和成像方面的互补专业知识 分析/计算机视觉，以解决生物医学科学中的关键知识差距。项目联席主任将专注于 在脊椎动物眼睛的发育上，因此将直接与细胞信号相一致 爱达荷州INBRE-4计划的科学主题，因为该机构开展了许多发展和功能 信令活动。本补充项目将探讨下列关系的时空动态 使用实时共聚焦成像研究发育中的神经前体细胞、神经元、胶质细胞和非神经系统细胞类型 斑马鱼胚胎，以及图像/视频分析的新方法。该项目将生成引用静态和 脊椎动物眼睛在视网膜发育/分化和创造时间内的动态图谱 视觉科学界的图像和视频分析工具，用于系统和定量比较 眼睛的表型。这些资源将向公众开放和互动，并将利用INBRE数据 科学核心设施在用户界面。该核心及其基础设施曾经或正在由IDEA(Cobre和 INBRE)奖项，并在机构上由UI颁发。三位项目联席总监，DL Stenkamp，DM Mitchell和L 阮氏所有人都有良好的研究记录，并指导过许多学员。这份副刊进一步加强了他们的 小组方法，并将为今后的协作研究和竞争性赠款提案提供初步数据， 遵守本基金补充条款的目标。这种团队科学方法将使每个研究人员受益。 通过他们的集体努力，并带来新的视角来解决发展中的这一关键知识差距 生物学。项目研究问题不会重复母公司爱达荷州目前正在进行的问题 INBRE-4项目奖。INBRE-4的团队科学附录鼓励竞争，这将 继续对爱达荷州的生物医学研究和培训产生持久的影响。

PROJECT SUMMARY The goal of the Idaho INBRE-4 Program is to continue to augment and strengthen Idaho's capacity to perform and sustain biomedical research. This Team Science Supplement, Dynamic Cellular Events in Assembling the Vertebrate Eye, will advance this goal by bringing together three University of Idaho (UI) investigators with complementary expertise in developmental neurobiology, immunology/glial biology/imaging, and image analysis/computer vision to address a key knowledge gap in biomedical science. Project co-directors will focus on the development of the vertebrate eye, and therefore will be directly in alignment with the Cell Signaling scientific theme of the Idaho INBRE-4 Program, as this organ carries out numerous developmental and functional signaling activities. This Supplement project will pursue the spatiotemporal dynamics of relationships among neuronal progenitors, neurons, glia, and non-nervous system cell types using live confocal imaging of developing zebrafish embryos, and novel means of image/video analysis. The project will generate reference static and dynamic atlases of vertebrate eye development over the time of retinal development/differentiation and create image and video analysis tools for the vision science community for systematic and quantitative comparison of eye phenotypes. These resources will be made publicly accessible and interactive and will utilize the INBRE Data Science Core facility at the UI. This Core and its infrastructure were or are supported by IDeA (COBRE and INBRE) awards and institutionally by the UI. The three project co-directors, DL Stenkamp, DM Mitchell, and L Nguyen all have strong research records and have mentored numerous trainees. This Supplement furthers their team approach and will provide preliminary data for future collaborative studies and competitive grant proposals, complying with the goal of this funding Supplement. This team science approach will benefit each investigator through their collective effort and bring new perspectives to address this key knowledge gap in developmental biology. The project research questions do not duplicate those currently being pursued by the parent Idaho INBRE-4 Program award. This Team Science Supplement to INBRE-4 encourages competitiveness that will continue to have an enduring impact on biomedical research and training in Idaho.