TIMED BIORESORBABLE Y 90 MICROSPHERES FOR RADIOTHERAPY

描述：放射性物质从注射液中泄漏 部位降低治疗效果，诱导对正常 组织，并增加副作用（皮炎，神经炎）的风险， 继发性肿瘤（白血病和骨肉瘤）。 不溶性玻璃或 陶瓷微球可含有对注射部位的放射性 抑制渗漏，但也可能随后诱发炎症、恶化 组织，和纤维化，或导致物理损伤愈合/愈合 接头. 这些障碍可以通过一个新的、及时的- 生物可吸收磷酸钙微球。 这些微球可以 保持结构完整性30天（11个物理半- 为Y-90而生，即，在它们开始之前衰减到可忽略不计的活动） 以预定的速度溶解，在患者体内不留下任何物质， 引起刺激、堵塞或物理损伤。 这样做的目的 项目是制备和测试含Y-90的微球， 程序性生物吸收 玻璃组成范围和Y-90溶解度 玻璃将被建立。 体外性质 生物可吸收Y-90磷酸钙玻璃微球将 其特征在于，可以在实验室中进行后续测试 动物 Y-90微球的应用包括直接瘤内给药， 注射（输注近距离放射治疗）治疗肝癌， 胰腺、大脑等，类风湿关节炎的放射性滑膜切除术 关节炎

DESCRIPTION: Leakage of radioactive material away from the injection site reduces therapeutic efficacy, induces undesirable damage to normal tissues, and increases the risk of side effects (dermitis, neuritis) and secondary neoplasia (leukemia and osteosarcoma). Insoluble glass or ceramic microspheres may contain radioactivity to the injection site and inhibit leakage, but may also later induce inflammation, deterioration of tissues, and fibrosis, or cause physical damage to healing/healed joints. These obstacles may be overcome with a new, timed- bioresorbable calcium phosphate microspheres. These microspheres can be made to maintain structural integrity for 30 days (11 physical half- lives for Y-90, i.e., decayed to negligible activity) before they begin to dissolve at a predetermined rate, leaving nothing in the patient to cause irritation, blockage or physical damage. The purpose of this project is to prepare and test Y-90-containing microspheres with pre- programmed bioresorption. Glass composition range and Y-90 solubility in glasses will be established. The in vitro properties of bioresorbable Y-90 calcium phosphate glass microspheres will be characterized so that follow-up tests can be conducted in laboratory animals. Applications of Y-90 microspheres include direct intratumoral injection (infusional brachytherapy) in treatment of cancers of liver, pancreas, brain, etc., and radiation synovectomy of rheumatoid arthritis.