EXERCISE LEVEL EFFECTS ON CHD RISK FACTORS

目前的政府指导方针建议成年人参加30 在大多数日子里， 周为了更好地了解身体的潜在健康益处， 活动超出目前的指导方针，我们建议审查 医生提供的冠心病风险 身体活动量和强度的因素测量 在17，287名跑步者（13，595名男性，3，692名女性）中， 两页的体力活动问卷数据来自9，125名跑步者 输入并验证到数据库中，数据来自另一个 8，162名参赛者已报名，但需要验证。数据集 构成了最大的跑步者脂蛋白样本 测量，实际上大于所有测量的总和。 先前发表的关于跑步者HDL-胆固醇的研究。 先前对这些数据的分析表明， 通过每小时至少跑40英里来改善风险因素 周小额赠款将使我们能够进一步评估 运动强度的重要性以及 年龄、饮食、肥胖和药物使用。具体目标是： 1)评估跑步强度是否会影响CHD危险因素， 根据行驶里程调整。 目前的指导方针指出， 身体活动的益处主要取决于总量 活动而不是强度。 2)评估跑步里程、 跑步强度和冠心病危险因素水平受年龄的影响， 饮食、当前肥胖或药物使用。 3)评估跑步是否可以预防女性中年体重 怀孕后体重增加和保持。(We表明 男性有增加体重和腹内脂肪的倾向 除非每周跑步距离每年增加，否则跑步里程数。 统计功效计算（α = 0.05，β = 0.2，双尾检验） 这表明假设的锻炼效果应该是可检测的。 这些数据是作为50，00美元香农奖的一部分收集的， 博士威廉姆斯为目的招募跑者进行详细的 脂蛋白的研究这一小笔赠款的所有假设 建议与香农奖的目标重叠， 没有资金进一步分析这些数据。的 结果与估计的运动习惯直接相关 一千八百万美国人为了健康而跑步或慢跑。

Current government guidelines recommend that adults engage in 30 minutes of moderate intensity physical activity for most days of the week. To better understand the potential health benefits of physical activity that exceed current guidelines, we propose to examine the relation of physician-supplied coronary heart disease (CHD) risk factor measurements to the amount and intensity of physical activity in 17,287 runners (13,595 male, 3,692 female) who completed a two-page physical activity questionnaire. Data from 9,125 runners are entered and verified into the database, data from an additional 8,162 runners are entered but require verification. The data set constitutes the largest existing sample of runners lipoprotein measurements, larger in fact than the combined total of all previously published studies of HDL-cholesterol in runners. Previous analyses of these data have demonstrated substantial CHD risk factor improvements through running at least 40 miles per week. The small grant award will enable us to assess further the importance of exercise intensity and the mitigating influences of age, diet, adiposity, and medication use. Specific objectives are to: 1)Assess whether running intensity affects CHD risk factors when adjusted for running mileage. Current guidelines state that the benefits of physical activity depend principally on the total amount of activity rather than intensity. 2)Assess whether the relationships between running mileage, running intensity and CHD risk factor levels are affected by age, diet, current adiposity, or medication use. 3)Assess whether running prevents women's middle-aged weight gain and weight retention after pregnancy. (We have shown that men have a propensity to gain weight and intra-abdominal fat at all running mileages unless weekly distance run is increased annually). Statistical power calculations (alpha:=O.05,beta=O.2,2-tailed test) suggest that the hypothesized exercise effects should be detectable. The data were collected as part of the $50,00() Shannon Award to Dr. Williams for the purpose of recruiting runners for a detailed study of lipoproteins. None of the hypotheses of this small grant proposal overlap with the aims of the Shannon Award, and there are no funds available for the further analysis of these data. The results are directly relevant to the exercise habits of the estimated eighteen million Americans who run or jog for health.