10 ELECTRON ELECTROPHILIC FLUORINATING AGENTS

有机氟化合物被广泛用作化疗药物。更多 最近，18F标记的化合物在正电子发射中变得重要起来 体层摄影术。虽然各种氟化剂和氟化 已知的方法很少有已知的引入氟的方法 转化为富含电子的体系，如烯烃、芳烃等。 绝大多数氟化剂都是亲核试剂。因为氟是 在已知的电负性最强的元素中，很少有 亲电氟化试剂是可用的。我们建议，作为 FIRCA拨款，用于准备和研究10电子等电子 Xe(II)、Se(IV)、Te(IV)、Bi(V)等 所提出的化学类似于化学。 正在经历文艺复兴的碘(III)。具体来说，ArSeF3， ArTeF3和Ar3BiF2以及XeF2将作为氟化进行调查 烯烃的试剂。同样，FXeOSO2F、FXeOSO2CF3和Xe(OSO2F)2， Xe(OSO2CF3)2将作为亲电引入的一种手段进行研究 将这些氟磺酸基团转化为烯烃。生物活性 像氟类固醇这样的化合物将与其他 医学上有用的含氟化合物。

Organo-fluorine compounds are widely used as chemotherapeutic agents. More recently 18F-labeled compounds have become important in positron emission tomography. Although a variety of fluorinating agents and fluorinating methods are known there are very few known ways of introducing fluorine into electron rich systems such as olefins, aromatics, etc. In fact the great majority of fluorinating agents are nucleophilic. Since fluorine is the most electronegative element known it is not surprising that few electrophilic fluorinating reagents are available. We propose, as part of a FIRCA grant, to prepare and investigate 10-electron isoelectronic Xe(II), Se(IV), Te(IV) and Bi(V) as "power variable electrophilic fluorinating agents". The proposed chemistry is analogous to the chemistry of Iodine (III) that is experiencing a Renaissance. Specifically, ArSeF3, ArTeF3 and Ar3BiF2 along with XeF2 will be investigated as fluorinating agents for olefins. Likewise FXeOSO2F, FXeOSO2CF3 and Xe(OSO2F)2, Xe(OSO2CF3)2 will be investigated as a means of electrophilic introduction of these fluorosulfonate groups into olefins. Biologically active compounds such as fluorosteroids will be prepared along with other medicinally useful fluorocompounds.