PHYSIOLOGICAL RESPONSES TO TONES IN ACUTE PTSD

创伤性事件的生理反应与心理健康的关系 以及随后发生的创伤后应激障碍(PTSD) 仍然是默默无闻和未被调查的。本项目将尝试澄清 通过扩展PI和同事之前的工作来建立这种关系 在慢性创伤后应激障碍患者中对严重创伤的受试者进行测试。这 以前的工作已经证明了存在升高的、较差的 习惯化对高音的生理反应 慢性创伤后应激障碍飞行员17例的刺激反应 根据本文提出的方法研究的创伤受害者是 极有希望证实 建议的工作是，存在体型大、适应性差的自主神经和 创伤事件后不久，对响亮音调的眨眼反应将 预测几个月后的创伤后应激障碍结果。 学科候选人将从患者群体中招募 向一家以色列大学医院的急诊室做演讲 经历过符合DSM-III-R“A”的心理创伤事件 创伤后应激障碍标准。在指数之后的一周内进行初步评估 创伤性事件，受试者的眼轮匝肌肌电(EMG)， 皮肤电导和心率对一系列响声的反应 将对演示文稿进行测量。在随后的评估中，执行了一项 在索引事件后六个月，将对主题进行评估 对于创伤后应激障碍和其他精神障碍的存在 临床医生使用的创伤后应激障碍量表(CAPS)和针对DSM的结构化访谈- III-R(SCID)。音调程序将重复，受试者也将 使用脚本进行进一步的心理生理创伤后应激障碍评估- 驱动成像程序。一些与创伤后应激障碍相关的心理测量学 还将获得措施。 声调呈现的生理反应之间的关系 在一周的评估和一个月和六个月的创伤后应激障碍结果 评估将通过Logistic回归的方式进行评估。一个数字 其他预测变量，以及潜在的混杂变量，将 进入分析以计算调整后的 创伤后应激障碍的优势比。

The relationship between the physiological reaction to a traumatic event and the subsequent development of post-traumatic stress disorder (PTSD) remains obscure and uninvestigated. This project will attempt to clarify this relationship by extending previous work of the PI's and colleagues' performed in chronic PTSD patients to acutely traumatized subjects. This previous work has demonstrated the presence of elevated, poorly habituating physiological responses to the presentation of loud tone stimuli in subjects with chronic PTSD Pilot data from seventeen acute trauma victims studied according to the methodology proposed herein are highly promising for confirmation of the central hypothesis of the proposed work that the presence of large, poorly habituating autonomic and eyeblink responses to loud tones shortly after a traumatic event will predict the PTSD outcome months later. Subject candidates will be recruited from the population of patients presenting to an Israeli University Hospital Emergency Room who have just experienced psychologically traumatic events that meet the DSM-III-R "A" PTSD criterion. At an initial assessment one week following the index traumatic event, the subject's orbicularis oculi electromyogram (EMG), skin conductance, and heart rate responses to a series of loud tone presentations will be measured. At subsequent assessments performed one and six months following the index event, the subject will be evaluated for the presence of PTSD and other mental disorders by means of the Clinician-Administered PTSD Scale (CAPS) and Structured Interview for DSM- III-R (SCID). The tone procedure will be repeated, and subjects will also undergo a further psychophysiological PTSD assessment using a script- driven imagery procedure. A number of PTSD-related and other psychometric measures will also be obtained. The relationship between physiological responses to the tone presentations at the one-week assessment and the PTSD outcome at the one- and six-month assessments will be evaluated by means of logistic regression. A number of other predictor variables, and potentially confounding variables, will be entered into the analysis for the purpose of calculating the adjusted odds ratio for PTSD.