Smoking, alcohol and NHL: an InterLymph-based analysis

描述(由申请人提供)： 在过去的几十年里，非霍奇金淋巴瘤(NHL)的发病率在世界各地的男性和女性中都急剧上升。然而，几乎没有确定非霍奇金淋巴瘤的具体危险因素。吸烟和饮酒被认为是可能影响非霍奇金淋巴瘤风险的两个因素。由于这些暴露在人群中的流行，了解这些行为在NHL病因学中的作用是至关重要的。2000年，23.3%的美国成年人报告目前吸烟，48.4%的成年人报告目前经常饮酒。然而，由于样本量相对较小，调查吸烟和饮酒对非霍奇金淋巴瘤风险的流行病学研究得出了不一致的结果。一些流行病学研究表明，吸烟和饮酒导致非霍奇金淋巴瘤的风险因疾病亚型和饮酒类型而异。然而，由于样本量小，个体流行病学研究考虑酒精类型和疾病亚型的风险因素对非霍奇金淋巴瘤的影响的能力一直受到限制。考虑到吸烟和饮酒的普遍性，以及围绕这些暴露与非霍奇金淋巴瘤风险之间关系的不确定性，迫切需要使用更大的样本量来评估吸烟和饮酒对非霍奇金淋巴瘤的影响。致力于淋巴瘤流行病学研究的国际研究人员联盟(InterLymph)的成立是为了促进大型NHL流行病学研究之间的合作，为我们提供了一个独特的机会来探索吸烟、酒精和NHL之间的关系。因此，我们建议对来自几个基于人群的病例对照研究的数据进行汇集分析，这些研究是InterLymph的一部分。由于最近成立了InterLymph，拟议的汇集分析是从这一国际合作中受益的第一次机会。这项综合分析的主要具体目的是确定非霍奇金淋巴瘤的风险是否与吸烟和饮酒有关，以及这种风险是否因疾病亚型和酒精类型而异。这项基于InterLymph的汇集分析将包括三项具有类似研究设计的基于人群的病例对照研究，结果是来自六个SEER地点的总共3,592例经组织学确认的事件病例和4,333例基于人群的对照。几项大型流行病学研究的合作将导致样本量的增加，这将使我们能够有足够的统计能力来检查吸烟、酒精和非霍奇金淋巴瘤之间的联系的强度和一致性。

DESCRIPTION (provided by applicant): Over the past several decades, incidence rates of non-Hodgkin's lymphoma (NHL) have increased dramatically throughout the world among both men and women. However, few concrete risk factors for NHL have been identified. Cigarette smoking and alcohol consumption have been proposed as two factors that could potentially impact the risk of NHL. Understanding the role of these behaviors in the etiology of NHL is critical due to the population prevalence of these exposures. In 2000, 23.3 percent of adults in the US reported current cigarette smoking, and 48.4 percent of adults reported current, regular consumption of alcohol. However, epidemiologic studies that have investigated the impact of cigarette smoking and alcohol on the risk of NHL have yielded inconsistent results due to relatively small sample sizes. Several epidemiologic studies have suggested that the risk of NHL from cigarette smoking and alcohol consumption varies by disease subtype and by the type of alcohol consumed. However, individual epidemiologic studies have been limited in their ability to consider the impact of risk factors on NHL by alcohol type and disease subtype because of small sample sizes. Considering the prevalence of cigarette smoking and alcohol consumption and the uncertainty surrounding the relationship between these exposures and risk of NHL, there exists an urgent need to assess the impact of smoking and drinking on NHL using a larger sample size. The International Consortium of Investigators Working on Lymphoma Epidemiologic Studies (InterLymph) was established to facilitate the cooperation between large, epidemiologic studies of NHL, providing us with a unique opportunity to explore the relationships between smoking, alcohol, and NHL. Therefore, we propose to conduct a pooled analysis of data from several population-based case-control studies that are a part of InterLymph. Due to the recent establishment of InterLymph, the proposed pooled analysis represents the first opportunity to benefit from this international collaboration. The primary specific aim of this pooled analysis is to determine if the risk of NHL is associated with cigarette smoking and alcohol consumption, and whether this risk varies by disease subtype and type of alcohol. This InterLymph-based pooled analysis will include three population-based case-control studies with similar study design, resulting in a total of 3,592 histologically-confirmed, incident cases and 4,333 population-based controls, from six SEER sites. The increased sample size that will result from the collaboration of several large, epidemiologic studies will enable us to have sufficient statistical power to examine the strength and consistency of the associations between smoking, alcohol, and NHL.