Malt Liquor Preference-Pharmacokinetics in Afri-American

描述（由申请人提供）： 酗酒在非洲产生社会，环境和医疗后果 给美国带来毁灭性的经济后果。的总体目标 一项研究旨在确定高酒精含量 麦芽啤酒的含量以及这种饮料对增加 城市非裔美国人的消费模式， 以前在大多数研究活动中代表不足。的意义 麦芽酒作为酒精中毒或酒精滥用的一个促成因素 还没有在任何人群中进行过任何重要的研究。研究 设计解决了三个重要的问题：麦芽的消费如何 与饮酒、心理社会表型和 酒精问题的发展，包括酒精滥用和依赖。 是 麦芽酒的消费模式与年龄有关， 社会经济地位？酒精的药代动力学是否存在差异 口服麦芽酒后的吸收和/或消除？ 提出了两个具体目标：（1）使用基于人群的研究设计， 识别与酒精饮料偏好相关的特定用户特征 包括使用频率和消费水平、经济、心理社会 行为和环境因素以及ADH基因型在300名队列中的分布 城市非洲裔美国男性，特别强调 麦芽酒精饮料偏好这些因素。的贡献 发展中的广告、烟草使用和精神等因素 麦芽酒的偏好也将被探讨。根据这些数据，临床 这些饮料的主动依赖和非依赖使用者的表型 （2）采用交叉研究设计， 将招募21-25岁的非酒精依赖性非裔美国男性， 确定和量化酒精药代动力学的生物学差异 急性口服普通啤酒和/或麦芽酒后， 不同的酒精浓度，使用口服酒精激发模型 包含旨在减少受试者变异性的内部控制。的 拟议研究的理由得到了加强， 众多发达的受试者招募网站，现有的科学和 行政团队，以应对征聘大批族裔 同质的队列，大量现有的培训/经验， 使用类似的测试仪器和临床程序， 提供NIH资助的GCRC，能够支持口服酒精 挑战研究，以及行政和科学基础设施， NIAAA酒精合作研究中心。从这些研究中，我们 了解影响麦芽偏好的关键因素 酒将被确定和生物基础的推定 将描述酒精药代动力学的差异。

DESCRIPTION (provided by applicant): Alcoholism produces social, environmental and medical outcomes in African Americans with devastating economic consequences. The overall goal of the proposed research is to determine the relationship between high alcohol content malt Beverages and the contribution such beverages make to increased consumption patterns among urban African Americans, a study population previously under represented in most research activities. The significance of malt liquor as a contributing specific factor in alcoholism or alcohol abuse has not been studied to any significant degree in any population. The study design addresses three important questions: How is the consumption of malt liquor associated with the onset of drinking, psycho-social phenotypes and the development of alcohol problems, including alcohol abuse and dependence. Are there differences in malt liquor consumption patterns related to age, and socioeconomic status? Are there pharmacokinetic differences in alcohol absorption and/or elimination following the oral ingestion of malt liquors? Two Specific Aims are proposed: (1) Using a population-based study design, identify specific user characteristics related to alcohol beverage preferences including use frequency and consumption levels, economic, psychosocial, behavioral and environmental factors, and ADH genotype among a cohort of 300 urban African American males with specific emphasis on the relationship of malt alcoholic beverage preference to these factors. The contribution of factors such as advertising, tobacco use and spirituality in the development of malt liquor preference will also be explored. From these data, a clinical phenotype of an active dependent and non-dependent user of these beverages will be identified, and (2) Using a cross-over study design, sixty healthy non-alcohol dependent African American males, age 21-25 will be recruited to determine and quantify biological differences in alcohol pharmacokinetics following the acute oral consumption of regular beer and/or malt liquors of varying alcohol concentrations, using an oral alcohol challenge model containing internal controls designed to reduce subject variability. The rationale for the proposed study is strengthened by the availability of numerous well developed subject recruitment sites, an existing scientific and administrative team to meet the challenge of recruiting a large ethnically homogenous cohort, substantial existing training/experience in the administration of similar test instruments and clinical procedures, availability of a NIH funded GCRC with the ability to support the oral alcohol challenge studies, and the administrative and scientific infrastructure of a NIAAA Collaborative Alcohol Research Center. From these studies, our understanding of the critical factors influencing the preference for malt liquor will be identified and the biological basis for the presumed differences in alcohol pharmacokinetics will be described.