Conference on Muscle: Excitation-Contraction Coupling

描述(由申请人提供)： 这是一项为将于2003年6月举行的戈登肌肉研究会议：兴奋-收缩(E-C)耦合提供部分资金的建议。E-C偶联是将肌肉动作电位转化为[Ca~(2+)]i升高和收缩的过程。最近的进展使人们有必要了解E-C偶联的分子事件，特别是E-C偶联的两个膜内分子-肌浆网钙释放通道或ryanodine受体(RyR)和横管电压传感器或二氢吡啶受体(DHPR)之间的相互作用。这次会议将汇集膜蛋白结构、人类遗传学、分子生物学、生物化学、生物物理学和生理学方面的专家，讨论将促进对骨骼肌中钙信号的分子理解的方法，并对其他组织产生影响。这个不同的小组考虑的问题将从分子结构到分子操作的生理结果和肌肉激活的关键蛋白质的修饰。会议将在9个平台会议上集中讨论骨骼肌中钙信号的几个关键方面：(1)关键蛋白的细胞组织和分子结构；(2)DHPR和RyR之间的分子相互作用；(3)E-C偶联蛋白缺陷引起的遗传性肌肉疾病的分子基础和病理生理；(4)钙释放的基本事件；(5)辅助蛋白和RyR功能的生化调节；(6)E-C偶联成分的分子操纵和表达；(7)肌纤维中的全球钙瞬变和疲劳；(8)肌肉和其他细胞中的转录偶联；(9)肌肉中的其他钙离子途径。海报将持续展示。戈登肌肉会议：几十年来每三年举行一次的E-C耦合会议，一直是来自世界各地的活跃研究人员聚集在一起讨论和传播导致该领域取得进展的想法的唯一论坛。该格式鼓励思想和未公布数据的自由交流。组委会和会议领导人将努力实现妇女、少数群体和残疾人的适当代表性。所有设施都是无障碍的。

DESCRIPTION (provided by applicant): This is a proposal for partial funding of a Gordon Research Conference on Muscle: Excitation-Contraction (E-C) Coupling to be held in June 2003. E-C coupling is the process that translates a muscle action potential into an increase in [Ca2+]i and contraction. Recent advances have brought into sharp focus the necessity of understanding the molecular events that underlie E-C coupling, in particular, the interaction between the two intramembrane molecules that are key to E-C coupling, the sarcoplasmic reticulum Ca2+ release channel or ryanodine receptor (RyR) and the transverse tubule voltage sensor or dihydropyridine receptor (DHPR). The meeting will bring together specialists in membrane protein structure, human genetics, molecular biology, biochemistry, biophysics and physiology to discuss the approaches that will advance molecular understanding of Ca2+ signaling in skeletal muscle, with implications for other tissues. The problems considered by this diverse group will range from molecular structure through the physiological results of molecular manipulation and modification of the key proteins underlying muscle activation. The meeting will focus discussion on several key aspects of Ca2+ signaling in skeletal muscle in nine platform sessions: (1) cellular organization and molecular structures of key proteins; (2) molecular interactions between DHPR and RyR; (3) molecular basis and pathophysiology of inherited muscle diseases caused by defects in E-C coupling proteins; (4) elementary events of Ca2+ release; (5) accessory protein and biochemical modulation of RyR function; (6) molecular manipulation and expression of E-C coupling components; (7) global calcium transients and fatigue in muscle fibers; (8) excitation transcription coupling in muscle and other cells; (9) other Ca2+ pathways in muscle. Posters will be shown continuously. The Gordon Conference on Muscle: E-C coupling, held every three years for several decades, has consistently been the sole forum in which active investigators from all over the world are brought together for discussion and dissemination of ideas that have led to advances in this field. The format encourages free exchange of ideas and unpublished data. The organizing committee and session leaders will strive to achieve appropriate representation of women, minorities and disabled. All facilities are handicapped accessible.