Field Cooling System for Therpeutic Hypothermia

描述(由申请人提供)： 最近的临床研究表明，心脏骤停后亚低温治疗对神经系统预后有显著益处。据推测，这种治疗可以越早开始，潜在的好处就越大，可能受益的患者数量也就越多。然而，目前还没有为急救人员或急救人员提供现场降温的实用方法。机械冷却系统耗电量大、重量重且价格昂贵。冰袋和化学冰袋在野外储存、运输、湿时病人治疗以及缺乏温度控制等方面存在许多明显的实际问题。在拟议的工作中，将采用一种新的宇航服冷却技术，以提供可靠、轻便、廉价、非常低功率、易于控制的冷却源，使轻度治疗性低温治疗能够在心脏复苏后立即在现场早期开始。建议的冷却系统是基于可再生热吸收的。在第一阶段，将制造一台制冷能力约为200W-hr的概念验证冷却器和一个冷却垫，并在台式和动物实验中进行演示。在第一阶段，将开发和演示一个完整的原型。

DESCRIPTION (provided by applicant): Recent clinical research indicates a significant benefit to neurological outcomes associated with mild therapeutic hypothermia after cardiac arrest. Presumably, the sooner such treatment can begin, the greater the potential benefit and the greater the number of patients who might benefit. However, there is presently no practical way for paramedics or first responders to provide cooling for hypothermia in the field. Mechanical cooling systems are power hungry, heavy, and expensive. Ice and chemical ice packs have many obvious practical problems with field storage, transport, patient treatment when wet, and lack of temperature control. In the proposed effort, a novel spacesuit cooling technology will be adapted to provide a reliable, lightweight, inexpensive, very low power, easily controlled cooling source that will enable mild therapeutic hypothermia treatment to begin early in the field immediately after cardiac resuscitation. The proposed cooling system is based on regenerable heat absorption. During Phase I, a proof-of-concept cooler with a capacity of approximately 200 W-hr of refrigeration and a cooling pad will be fabricated and demonstrated in bench top and animal experiments. During Phase I, a complete prototype will be developed and demonstrated.