Kits for Converting Nanocrystals to Bio-Reagents

描述（由申请人提供）：该NIH SBIR计划旨在最终将高质量的胶体纳米晶体（主要是半导体纳米晶体，并对贵金属纳米晶体有一些关注）转化为标准生物医学试剂。该计划基于我们正在申请专利的配体化学和胶体纳米晶体生物共轭化学技术。胶体纳米晶体是相应大块晶体的纳米尺寸片段，其通常在溶液中合成和操作。它们强大的尺寸依赖性和灵活的溶液相加工性能使它们成为许多生物医学应用的理想候选者，例如生物医学标记标签，药物递送载体，MRI增强试剂等。这些应用的两个关键挑战是高质量纳米晶体的商业规模生产及其可靠的生物共轭化学。第一个问题是由该公司的两个NSF SBIR计划解决的。这个NIH SBIR计划将解决第二个问题，生物共轭化学。该计划的成功将为学术和工业科学家/工程师以及医务工作者提供稳定，可靠，廉价和简单的方法，以在他们的研究，开发和其他日常工作中应用高质量的纳米晶体。这一目标将通过为胶体纳米晶体的生物医学应用设计和开发三个互补系列的配体化学和生物缀合化学试剂盒来实现。

DESCRIPTION (provided by applicant): This NIH SBIR program intends to ultimately convert high quality colloidal nanocrystals, mainly semiconductor nanocrystals and with some concerns on noble metal nanocrystals, to standard bio-medical reagents. This program is based on our patent-pending technologies for ligand chemistry and bio-conjugation chemistry for colloidal nanocrystals. Colloidal nanocrystals are nanometer-sized fragments of corresponding bulk crystals, which are typically synthesized and manipulated in solution. Their strong size dependent properties and flexible solution-phase processability make them as ideal candidates for many bio-medical applications, such as bio-medical labeling tags, drug delivery carriers, MRI enhancing reagents, etc. The two key challenges for such applications are the commercial scale production of high quality nanocrystals and their reliable bio-conjugation chemistry. The first issue is being addressed by two NSF SBIR programs in this company. This NIH SBIR program will address the second issue, bio-conjugation chemistry. The success of this program will provide academic and industrial scientists/engineers as well as medical workers stable, reliable, inexpensive and simple means to apply high quality nanocrystals in their research, development and other daily duties. This goal will be accomplished by design and development of three complementary series of ligand chemistry and bio-conjugation chemistry kits for the bio-medical applications of colloidal nanocrystals.