BIOELECTRONIC MICROARRAY FOR DNA ANALYSIS

在这个项目中，我们提出了一种新的检测技术，用于识别寡核苷酸，其工作原理是通过检测杂交双链体的生物电子响应。与使用染料标记的寡核苷酸的传统方法相比，所提出的电化学检测器具有显着的优势。电化学传感可以使用相对简单的设备来实现。分析可以在溶液中进行。在所提出的方法中，不需要标记靶分子。当完全开发时，以前为成像应用开发的高度集成的电子芯片可以被修改，并可以用作新一代廉价的一次性电化学DNA微阵列传感器。

In this project, we propose a new detection technology for identification of oligonucleotides, which works by detecting a bio-electronic response from hybridized duplexes. Compared with the conventional approach of using dye tagged oligos, the proposed electrochemical detector has significant advantages. Electrochemical sensing can be implemented using relatively simple equipment. Analysis can be performed in solution. In the proposed approach, no tagging of target molecules is required. When fully developed, highly integrated electronic chips, previously developed for imaging applications, can be modified and can be used as a new generation of inexpensive, disposable, electrochemical DNA microarray sensors.